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Gitelman's syndrome with panhypopituitarism: Reno-endocrine interplay

Gitelman's syndrome is an inherited tubulopathy affecting thiazide-sensitive sodium chloride cotransporter, which manifests with hypokalemic alkalosis, hypomagnesemia, and hypocalciuria. Recently few cases have been described having an association of Gitelman's syndrome with pituitary abno...

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Detalles Bibliográficos
Autores principales: Upreti, Vimal, Sharda, Chetan, Kumar, B. V. N, Dhull, Pawan, Prakash, M. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3313754/
https://www.ncbi.nlm.nih.gov/pubmed/22470873
http://dx.doi.org/10.4103/2230-8210.93774
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author Upreti, Vimal
Sharda, Chetan
Kumar, B. V. N
Dhull, Pawan
Prakash, M. S.
author_facet Upreti, Vimal
Sharda, Chetan
Kumar, B. V. N
Dhull, Pawan
Prakash, M. S.
author_sort Upreti, Vimal
collection PubMed
description Gitelman's syndrome is an inherited tubulopathy affecting thiazide-sensitive sodium chloride cotransporter, which manifests with hypokalemic alkalosis, hypomagnesemia, and hypocalciuria. Recently few cases have been described having an association of Gitelman's syndrome with pituitary abnormalities on imaging, though with normal hormonal status. We describe the first case of an adult patient having Gitelman's syndrome and hypopituitarism with abnormal pituitary imaging. She presented to us with hypotension, hypokalemia, hypomagnesemia with alkalosis, hypothyroidism, hypocortisolism, and hypogonadism. She was treated with replacement of electrolytes and hormones, to which she showed an excellent response.
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spelling pubmed-33137542012-04-02 Gitelman's syndrome with panhypopituitarism: Reno-endocrine interplay Upreti, Vimal Sharda, Chetan Kumar, B. V. N Dhull, Pawan Prakash, M. S. Indian J Endocrinol Metab Case Report Gitelman's syndrome is an inherited tubulopathy affecting thiazide-sensitive sodium chloride cotransporter, which manifests with hypokalemic alkalosis, hypomagnesemia, and hypocalciuria. Recently few cases have been described having an association of Gitelman's syndrome with pituitary abnormalities on imaging, though with normal hormonal status. We describe the first case of an adult patient having Gitelman's syndrome and hypopituitarism with abnormal pituitary imaging. She presented to us with hypotension, hypokalemia, hypomagnesemia with alkalosis, hypothyroidism, hypocortisolism, and hypogonadism. She was treated with replacement of electrolytes and hormones, to which she showed an excellent response. Medknow Publications & Media Pvt Ltd 2012 /pmc/articles/PMC3313754/ /pubmed/22470873 http://dx.doi.org/10.4103/2230-8210.93774 Text en Copyright: © Indian Journal of Endocrinology and Metabolism http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Upreti, Vimal
Sharda, Chetan
Kumar, B. V. N
Dhull, Pawan
Prakash, M. S.
Gitelman's syndrome with panhypopituitarism: Reno-endocrine interplay
title Gitelman's syndrome with panhypopituitarism: Reno-endocrine interplay
title_full Gitelman's syndrome with panhypopituitarism: Reno-endocrine interplay
title_fullStr Gitelman's syndrome with panhypopituitarism: Reno-endocrine interplay
title_full_unstemmed Gitelman's syndrome with panhypopituitarism: Reno-endocrine interplay
title_short Gitelman's syndrome with panhypopituitarism: Reno-endocrine interplay
title_sort gitelman's syndrome with panhypopituitarism: reno-endocrine interplay
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3313754/
https://www.ncbi.nlm.nih.gov/pubmed/22470873
http://dx.doi.org/10.4103/2230-8210.93774
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