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KAI1 suppresses HIF-1α and VEGF expression by blocking CDCP1-enhanced Src activation in prostate cancer

BACKGROUND: KAI1 was initially identified as a metastasis-suppressor gene in prostate cancer. It is a member of the tetraspan transmembrane superfamily (TM4SF) of membrane glycoproteins. As part of a tetraspanin-enriched microdomain (TEM), KAI1 inhibits tumor metastasis by negative regulation of Src...

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Detalles Bibliográficos
Autores principales:	Park, Jung-Jin, Jin, Yeung Bae, Lee, Yoon-Jin, Lee, Jae-Seon, Lee, Yun-Sil, Ko, Young-Gyu, Lee, Minyoung
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3313899/ https://www.ncbi.nlm.nih.gov/pubmed/22390300 http://dx.doi.org/10.1186/1471-2407-12-81

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