Ligation Tunes Protein Reactivity in an Ancient Haemoglobin: Kinetic Evidence for an Allosteric Mechanism in Methanosarcina acetivorans Protoglobin

Protoglobin from Methanosarcina acetivorans (MaPgb) is a dimeric globin with peculiar structural properties such as a completely buried haem and two orthogonal tunnels connecting the distal cavity to the solvent. CO binding to and dissociation from MaPgb occur through a biphasic kinetics. We show th...

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Detalles Bibliográficos
Autores principales: Abbruzzetti, Stefania, Tilleman, Lesley, Bruno, Stefano, Viappiani, Cristiano, Desmet, Filip, Van Doorslaer, Sabine, Coletta, Massimo, Ciaccio, Chiara, Ascenzi, Paolo, Nardini, Marco, Bolognesi, Martino, Moens, Luc, Dewilde, Sylvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3313925/
https://www.ncbi.nlm.nih.gov/pubmed/22479420
http://dx.doi.org/10.1371/journal.pone.0033614

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