The Voltage–gated Proton Channel, Hv1, Enhances Brain Damage from Ischemic Stroke

Phagocytic cell NADPH oxidase (NOX) generates reactive oxygen species (ROS) as part of innate immunity. Unfortunately, ischemia can also induce this pathway and inflict damage on native cells. Here we show that NOX–mediated damage can be inhibited by suppression of the voltage-gated proton channel,...

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Detalles Bibliográficos
Autores principales: Wu, Long–Jun, Wu, Gongxiong, Akhavan Sharif, M. Reza, Baker, Amanda, Jia, Yonghui, H. Fahey, Frederic, Luo, Hongbo R., Feener, Edward P., Clapham, David E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314139/
https://www.ncbi.nlm.nih.gov/pubmed/22388960
http://dx.doi.org/10.1038/nn.3059

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