Automated image analysis of nuclear shape: What can we learn from a prematurely aged cell?

The premature aging disorder, Hutchinson-Gilford progeria syndrome (HGPS), is caused by mutant lamin A, which affects the nuclear scaffolding. The phenotypic hallmark of HGPS is nuclear blebbing. Interestingly, similar nuclear blebbing has also been observed in aged cells from healthy individuals. R...

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Detalles Bibliográficos
Autores principales: Driscoll, Meghan K., Albanese, Jason L., Xiong, Zheng-Mei, Mailman, Mitch, Losert, Wolfgang, Cao, Kan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2012
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314174/
https://www.ncbi.nlm.nih.gov/pubmed/22354768

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