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On-line electrochemistry–bioaffinity screening with parallel HR-LC-MS for the generation and characterization of modified p38α kinase inhibitors
In this study, an integrated approach is developed for the formation, identification and biological characterization of electrochemical conversion products of p38α mitogen-activated protein kinase inhibitors. This work demonstrates the hyphenation of an electrochemical reaction cell with a continuou...
Autores principales: | Falck, David, de Vlieger, Jon S. B., Giera, Martin, Honing, Maarten, Irth, Hubertus, Niessen, Wilfried M. A., Kool, Jeroen |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer-Verlag
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314180/ https://www.ncbi.nlm.nih.gov/pubmed/22227812 http://dx.doi.org/10.1007/s00216-011-5663-2 |
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