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Modulation of La Crosse Virus Infection in Aedes albopictus Mosquitoes Following Larval Exposure to Coffee Extracts

The mosquito-borne La Crosse virus (LACV; Family Bunyaviridae) may cause encephalitis, primarily in children, and is distributed throughout much of the eastern United States. No antivirals or vaccines are available for LACV, or most other mosquito-borne viruses, and prevention generally relies on mo...

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Autores principales: Eastep, Nicole E., Albert, Rachel E., Anderson, Justin R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314198/
https://www.ncbi.nlm.nih.gov/pubmed/22470349
http://dx.doi.org/10.3389/fphys.2012.00066
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author Eastep, Nicole E.
Albert, Rachel E.
Anderson, Justin R.
author_facet Eastep, Nicole E.
Albert, Rachel E.
Anderson, Justin R.
author_sort Eastep, Nicole E.
collection PubMed
description The mosquito-borne La Crosse virus (LACV; Family Bunyaviridae) may cause encephalitis, primarily in children, and is distributed throughout much of the eastern United States. No antivirals or vaccines are available for LACV, or most other mosquito-borne viruses, and prevention generally relies on mosquito control. We sought to determine whether coffee extracts could interfere with LACV replication and vector mosquito development. Both regular and decaffeinated coffee demonstrated significant reductions in LACV replication in direct antiviral assays. This activity was not due to the presence of caffeine, which did not inhibit the virus life cycle. Aedes albopictus (Skuse; Diptera: Culicidae) mosquito larvae suffered near total mortality when reared in high concentrations of regular and decaffeinated coffee and in caffeine. Following larval exposure to sublethal coffee concentrations, adult A. albopictus mosquitoes had significantly reduced whole-body LACV titers 5 days post-infection, compared to larvae reared in distilled water. These results suggest that it may be possible to both control mosquito populations and alter the vector competence of mosquitoes for arthropod-borne viruses by introducing antiviral compounds into the larval habitat.
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spelling pubmed-33141982012-04-02 Modulation of La Crosse Virus Infection in Aedes albopictus Mosquitoes Following Larval Exposure to Coffee Extracts Eastep, Nicole E. Albert, Rachel E. Anderson, Justin R. Front Physiol Physiology The mosquito-borne La Crosse virus (LACV; Family Bunyaviridae) may cause encephalitis, primarily in children, and is distributed throughout much of the eastern United States. No antivirals or vaccines are available for LACV, or most other mosquito-borne viruses, and prevention generally relies on mosquito control. We sought to determine whether coffee extracts could interfere with LACV replication and vector mosquito development. Both regular and decaffeinated coffee demonstrated significant reductions in LACV replication in direct antiviral assays. This activity was not due to the presence of caffeine, which did not inhibit the virus life cycle. Aedes albopictus (Skuse; Diptera: Culicidae) mosquito larvae suffered near total mortality when reared in high concentrations of regular and decaffeinated coffee and in caffeine. Following larval exposure to sublethal coffee concentrations, adult A. albopictus mosquitoes had significantly reduced whole-body LACV titers 5 days post-infection, compared to larvae reared in distilled water. These results suggest that it may be possible to both control mosquito populations and alter the vector competence of mosquitoes for arthropod-borne viruses by introducing antiviral compounds into the larval habitat. Frontiers Research Foundation 2012-03-28 /pmc/articles/PMC3314198/ /pubmed/22470349 http://dx.doi.org/10.3389/fphys.2012.00066 Text en Copyright © 2012 Eastep, Albert and Anderson. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited.
spellingShingle Physiology
Eastep, Nicole E.
Albert, Rachel E.
Anderson, Justin R.
Modulation of La Crosse Virus Infection in Aedes albopictus Mosquitoes Following Larval Exposure to Coffee Extracts
title Modulation of La Crosse Virus Infection in Aedes albopictus Mosquitoes Following Larval Exposure to Coffee Extracts
title_full Modulation of La Crosse Virus Infection in Aedes albopictus Mosquitoes Following Larval Exposure to Coffee Extracts
title_fullStr Modulation of La Crosse Virus Infection in Aedes albopictus Mosquitoes Following Larval Exposure to Coffee Extracts
title_full_unstemmed Modulation of La Crosse Virus Infection in Aedes albopictus Mosquitoes Following Larval Exposure to Coffee Extracts
title_short Modulation of La Crosse Virus Infection in Aedes albopictus Mosquitoes Following Larval Exposure to Coffee Extracts
title_sort modulation of la crosse virus infection in aedes albopictus mosquitoes following larval exposure to coffee extracts
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314198/
https://www.ncbi.nlm.nih.gov/pubmed/22470349
http://dx.doi.org/10.3389/fphys.2012.00066
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