Cargando…

Glucagon-Like Peptide 1 Recruits Microvasculature and Increases Glucose Use in Muscle via a Nitric Oxide–Dependent Mechanism

Glucagon-like peptide 1 (GLP-1) increases tissue glucose uptake and causes vasodilation independent of insulin. We examined the effect of GLP-1 on muscle microvasculature and glucose uptake. After confirming that GLP-1 potently stimulates nitric oxide (NO) synthase (NOS) phosphorylation in endotheli...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chai, Weidong, Dong, Zhenhua, Wang, Nasui, Wang, Wenhui, Tao, Lijian, Cao, Wenhong, Liu, Zhenqi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2012
Materias:	Pathophysiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314347/ https://www.ncbi.nlm.nih.gov/pubmed/22357961 http://dx.doi.org/10.2337/db11-1073

Ejemplares similares

Glucagon-Like Peptide 1 Recruits Muscle Microvasculature and Improves Insulin’s Metabolic Action in the Presence of Insulin Resistance
por: Chai, Weidong, et al.
Publicado: (2014)

Angiotensin II Receptors Modulate Muscle Microvascular and Metabolic Responses to Insulin In Vivo
por: Chai, Weidong, et al.
Publicado: (2011)

Protein Engineering Strategies for Sustained Glucagon-Like Peptide-1 Receptor–Dependent Control of Glucose Homeostasis
por: Picha, Kristen M., et al.
Publicado: (2008)

The Glucagonostatic and Insulinotropic Effects of Glucagon-Like Peptide 1 Contribute Equally to Its Glucose-Lowering Action
por: Hare, Kristine J., et al.
Publicado: (2010)

Rapid Tachyphylaxis of the Glucagon-Like Peptide 1–Induced Deceleration of Gastric Emptying in Humans
por: Nauck, Michael A., et al.
Publicado: (2011)

Glucagon-Like Peptide 1 Receptor Activation Augments Cardiac Output and Improves Cardiac Efficiency in Obese Swine After Myocardial Infarction
por: Sassoon, Daniel J., et al.
Publicado: (2017)

Preserved glucagon-like peptide-1 responses to oral glucose, but reduced incretin effect, insulin secretion and sensitivity in young Asians with type 2 diabetes mellitus
por: Yeow, Toh Peng, et al.
Publicado: (2017)

Loss of Inverse Relationship Between Pulsatile Insulin and Glucagon Secretion in Patients With Type 2 Diabetes
por: Menge, Björn A., et al.
Publicado: (2011)

Glucagon-like peptide-1 receptor agonists are not associated with retinal adverse events in the FDA Adverse Event Reporting System
por: Fadini, Gian Paolo, et al.
Publicado: (2018)

Evidence Against an Important Role of Plasma Insulin and Glucagon Concentrations in the Increase in EGP Caused by SGLT2 Inhibitors
por: Alatrach, Mariam, et al.
Publicado: (2020)

Reduction in Basal Nitric Oxide Activity Causes Albuminuria
por: Ott, Christian, et al.
Publicado: (2011)

Impaired Glucagon-Mediated Suppression of VLDL-Triglyceride Secretion in Individuals With Metabolic Dysfunction–Associated Fatty Liver Disease (MAFLD)
por: Heebøll, Sara, et al.
Publicado: (2022)

The Insulin-Like Growth Factor-1 Receptor Is a Negative Regulator of Nitric Oxide Bioavailability and Insulin Sensitivity in the Endothelium
por: Abbas, Afroze, et al.
Publicado: (2011)

High Glucose Inhibits the Aspirin-Induced Activation of the Nitric Oxide/cGMP/cGMP-Dependent Protein Kinase Pathway and Does Not Affect the Aspirin-Induced Inhibition of Thromboxane Synthesis in Human Platelets
por: Russo, Isabella, et al.
Publicado: (2012)

Skeletal Muscle TRIB3 Mediates Glucose Toxicity in Diabetes and High- Fat Diet–Induced Insulin Resistance
por: Zhang, Wei, et al.
Publicado: (2016)

Differential Expression of Novel Adiponectin Receptor-1 Transcripts in Skeletal Muscle of Subjects With Normal Glucose Tolerance and Type 2 Diabetes
por: Ashwal, Reut, et al.
Publicado: (2011)

Na(+)-d-glucose Cotransporter SGLT1 is Pivotal for Intestinal Glucose Absorption and Glucose-Dependent Incretin Secretion
por: Gorboulev, Valentin, et al.
Publicado: (2012)

Interactions Among Glucose Delivery, Transport, and Phosphorylation That Underlie Skeletal Muscle Insulin Resistance in Obesity and Type 2 Diabetes: Studies With Dynamic PET Imaging
por: Goodpaster, Bret H., et al.
Publicado: (2014)

Distinct β-Cell Defects in Impaired Fasting Glucose and Impaired Glucose Tolerance
por: Kanat, Mustafa, et al.
Publicado: (2012)

GLP-1 and Insulin Recruit Muscle Microvasculature and Dilate Conduit Artery Individually But Not Additively in Healthy Humans
por: Tan, Alvin W.K., et al.
Publicado: (2018)

Muscle-Specific Vascular Endothelial Growth Factor Deletion Induces Muscle Capillary Rarefaction Creating Muscle Insulin Resistance
por: Bonner, Jeffrey S., et al.
Publicado: (2013)

Intergenerational Transmission of Glucose Intolerance and Obesity by In Utero Undernutrition in Mice
por: Jimenez-Chillaron, Josep C., et al.
Publicado: (2009)

Hypothalamic Vitamin D Improves Glucose Homeostasis and Reduces Weight
por: Sisley, Stephanie R., et al.
Publicado: (2016)

Impaired Glucose Tolerance in the Absence of Adenosine A1 Receptor Signaling
por: Faulhaber-Walter, Robert, et al.
Publicado: (2011)

Postprandial and Fasting Hepatic Glucose Fluxes in Long-Standing Type 1 Diabetes
por: Kacerovsky, Michaela, et al.
Publicado: (2011)

Brain Insulin Action Regulates Hypothalamic Glucose Sensing and the Counterregulatory Response to Hypoglycemia
por: Diggs-Andrews, Kelly A., et al.
Publicado: (2010)

High Glucose–Repressed CITED2 Expression Through miR-200b Triggers the Unfolded Protein Response and Endoplasmic Reticulum Stress
por: Gu, Hui, et al.
Publicado: (2016)

SGLT2 Deletion Improves Glucose Homeostasis and Preserves Pancreatic β-Cell Function
por: Jurczak, Michael J., et al.
Publicado: (2011)

B-Type Natriuretic Peptide Modulates Ghrelin, Hunger, and Satiety in Healthy Men
por: Vila, Greisa, et al.
Publicado: (2012)

Small Decrements in Systemic Glucose Provoke Increases in Hypothalamic Blood Flow Prior to the Release of Counterregulatory Hormones
por: Page, Kathleen A., et al.
Publicado: (2009)

Regulation of Mitochondrial Biogenesis by Lipoprotein Lipase in Muscle of Insulin-Resistant Offspring of Parents With Type 2 Diabetes
por: Morino, Katsutaro, et al.
Publicado: (2012)

Short-Term Caloric Restriction Normalizes Hypothalamic Neuronal Responsiveness to Glucose Ingestion in Patients With Type 2 Diabetes
por: Teeuwisse, Wouter M., et al.
Publicado: (2012)

Evidence for Interindividual Heterogeneity in the Glucose Gradient Across the Human Red Blood Cell Membrane and Its Relationship to Hemoglobin Glycation
por: Khera, Paramjit K., et al.
Publicado: (2008)

Xenin-25 Amplifies GIP-Mediated Insulin Secretion in Humans With Normal and Impaired Glucose Tolerance but Not Type 2 Diabetes
por: Wice, Burton M., et al.
Publicado: (2012)

The Role of Endogenous Incretin Secretion as Amplifier of Glucose-Stimulated Insulin Secretion in Healthy Subjects and Patients With Type 2 Diabetes
por: Woerle, Hans Juergen, et al.
Publicado: (2012)

Reduced β-Cell Secretory Capacity in Pancreatic-Insufficient, but Not Pancreatic-Sufficient, Cystic Fibrosis Despite Normal Glucose Tolerance
por: Sheikh, Saba, et al.
Publicado: (2017)

Altered Skeletal Muscle Lipase Expression and Activity Contribute to Insulin Resistance in Humans
por: Badin, Pierre-Marie, et al.
Publicado: (2011)

Angiotensin II Reduces Mitochondrial Content in Skeletal Muscle and Affects Glycemic Control
por: Mitsuishi, Masanori, et al.
Publicado: (2009)

Portal Vein Glucose Sensors Do Not Play a Major Role in Modulating Physiological Responses to Insulin-Induced Hypoglycemia in Humans
por: Rossetti, Paolo, et al.
Publicado: (2009)

Activin A Levels Are Associated With Abnormal Glucose Regulation in Patients With Myocardial Infarction: Potential Counteracting Effects of Activin A on Inflammation
por: Andersen, Geir Ø., et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_1g9b9n8ae80vkd28us8sucdcjm