Cargando…

Identification of Novel Type 1 Diabetes Candidate Genes by Integrating Genome-Wide Association Data, Protein-Protein Interactions, and Human Pancreatic Islet Gene Expression

Genome-wide association studies (GWAS) have heralded a new era in susceptibility locus discovery in complex diseases. For type 1 diabetes, >40 susceptibility loci have been discovered. However, GWAS do not inevitably lead to identification of the gene or genes in a given locus associated with dis...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bergholdt, Regine, Brorsson, Caroline, Palleja, Albert, Berchtold, Lukas A., Fløyel, Tina, Bang-Berthelsen, Claus Heiner, Frederiksen, Klaus Stensgaard, Jensen, Lars Juhl, Størling, Joachim, Pociot, Flemming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2012
Materias:	Genetics/Genomes/Proteomics/Metabolomics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314366/ https://www.ncbi.nlm.nih.gov/pubmed/22344559 http://dx.doi.org/10.2337/db11-1263

Ejemplares similares

Dissecting Human Gene Functions Regulating Islet Development With Targeted Gene Transduction
por: Pauerstein, Philip T., et al.
Publicado: (2015)

An Integrated Map of Cell Type–Specific Gene Expression in Pancreatic Islets
por: Elgamal, Ruth M., et al.
Publicado: (2023)

Novel Association Between Immune-Mediated Susceptibility Loci and Persistent Autoantibody Positivity in Type 1 Diabetes
por: Brorsson, Caroline A., et al.
Publicado: (2015)

Evidence of Gene-Gene Interaction and Age-at-Diagnosis Effects in Type 1 Diabetes
por: Howson, Joanna M.M., et al.
Publicado: (2012)

Epigenetic Changes in Islets of Langerhans Preceding the Onset of Diabetes
por: Ouni, Meriem, et al.
Publicado: (2020)

MicroRNAs and histone deacetylase inhibition-mediated protection against inflammatory β-cell damage
por: Lindeløv Vestergaard, Anna, et al.
Publicado: (2018)

Independent component and pathway-based analysis of miRNA-regulated gene expression in a model of type 1 diabetes
por: Bang-Berthelsen, Claus H, et al.
Publicado: (2011)

Effects of Non-HLA Gene Polymorphisms on Development of Islet Autoimmunity and Type 1 Diabetes in a Population With High-Risk HLA-DR,DQ Genotypes
por: Steck, Andrea K., et al.
Publicado: (2012)

The Type 1 Diabetes - HLA Susceptibility Interactome - Identification of HLA Genotype-Specific Disease Genes for Type 1 Diabetes
por: Brorsson, Caroline, et al.
Publicado: (2010)

Cathepsin C Regulates Cytokine-Induced Apoptosis in β-Cell Model Systems
por: Fløyel, Tina, et al.
Publicado: (2021)

Genetic Risk Score Modelling for Disease Progression in New-Onset Type 1 Diabetes Patients: Increased Genetic Load of Islet-Expressed and Cytokine-Regulated Candidate Genes Predicts Poorer Glycemic Control
por: Brorsson, Caroline A., et al.
Publicado: (2016)

DHA Supplementation Attenuates Inflammation-Associated Gene Expression in the Mammary Gland of Lactating Mothers Who Deliver Preterm
por: Adams, Joselyn M, et al.
Publicado: (2022)

Type 1 Diabetes Candidate Genes Linked to Pancreatic Islet Cell Inflammation and Beta-Cell Apoptosis
por: Størling, Joachim, et al.
Publicado: (2017)

Risk of Type 1 Diabetes Progression in Islet Autoantibody-Positive Children Can Be Further Stratified Using Expression Patterns of Multiple Genes Implicated in Peripheral Blood Lymphocyte Activation and Function
por: Jin, Yulan, et al.
Publicado: (2014)

Expression Profiling of Human Genetic and Protein Interaction Networks in Type 1 Diabetes
por: Bergholdt, Regine, et al.
Publicado: (2009)

A Transcription Start Site Map in Human Pancreatic Islets Reveals Functional Regulatory Signatures
por: Varshney, Arushi, et al.
Publicado: (2021)

Novel Human Insulin Isoforms and Cα-Peptide Product in Islets of Langerhans and Choroid Plexus
por: Liu, Qing-Rong, et al.
Publicado: (2021)

Association of TCF7L2 variation with single islet autoantibody expression in children with type 1 diabetes
por: Redondo, Maria J, et al.
Publicado: (2014)

Longitudinal Metabolome-Wide Signals Prior to the Appearance of a First Islet Autoantibody in Children Participating in the TEDDY Study
por: Li, Qian, et al.
Publicado: (2020)

hZnT8 (Slc30a8) Transgenic Mice That Overexpress the R325W Polymorph Have Reduced Islet Zn(2+) and Proinsulin Levels, Increased Glucose Tolerance After a High-Fat Diet, and Altered Levels of Pancreatic Zinc Binding Proteins
por: Li, Li, et al.
Publicado: (2017)

Insights Into the Molecular Mechanism for Type 2 Diabetes Susceptibility at the KCNQ1 Locus From Temporal Changes in Imprinting Status in Human Islets
por: Travers, Mary E., et al.
Publicado: (2013)

Large-Scale Analyses Provide No Evidence for Gene-Gene Interactions Influencing Type 2 Diabetes Risk
por: Nag, Abhishek, et al.
Publicado: (2020)

Metabolomic Changes in Serum of Children with Different Clinical Diagnoses of Malnutrition(1)(2)(3)
por: Di Giovanni, Valeria, et al.
Publicado: (2016)

Metabolic Footprinting of Fermented Milk Consumption in Serum of Healthy Men
por: Pimentel, Grégory, et al.
Publicado: (2018)

The Plasma Proteome Is Associated with Anthropometric Status of Undernourished Nepalese School-Aged Children(1)(2)(3)
por: Lee, Sun Eun, et al.
Publicado: (2017)

Identification of Milk and Cheese Intake Biomarkers in Healthy Adults Reveals High Interindividual Variability of Lewis System–Related Oligosaccharides
por: Pimentel, Grégory, et al.
Publicado: (2020)

Treatment with Nitrate, but Not Nitrite, Lowers the Oxygen Cost of Exercise and Decreases Glycolytic Intermediates While Increasing Fatty Acid Metabolites in Exercised Zebrafish
por: Axton, Elizabeth R, et al.
Publicado: (2019)

Personalized Profiling Reveals Donor- and Lactation-Specific Trends in the Human Milk Proteome and Peptidome
por: Zhu, Jing, et al.
Publicado: (2021)

Urine Metabolite Profiles and Nutrient Intake Based on 4-Day Weighed Food Diary in Habitual Vegans, Vegetarians, and Omnivores
por: Lindqvist, Helen M, et al.
Publicado: (2020)

Plasma MicroRNA Signature of Alcohol Consumption: The Rotterdam Study
por: Karabegović, Irma, et al.
Publicado: (2022)

Circulating Protein Signatures and Causal Candidates for Type 2 Diabetes
por: Gudmundsdottir, Valborg, et al.
Publicado: (2020)

A Gene-Family Analysis of 61 Genetic Variants in the Nicotinic Acetylcholine Receptor Genes for Insulin Resistance and Type 2 Diabetes in American Indians
por: Yang, Jingyun, et al.
Publicado: (2012)

Dataset of the frequency patterns of publications annotated to human protein-coding genes, their protein products and genetic relevance
por: Zwick, Matthias, et al.
Publicado: (2019)

Glutathione S-transferases gene polymorphism influence on the age of diabetes type 2 onset
por: Klusek, Justyna, et al.
Publicado: (2020)

Co-segregation analysis and functional trial in vivo of candidate genes for monogenic diabetes
por: Stankute, Ingrida, et al.
Publicado: (2022)

Association of the CDKAL1 gene polymorphism with gestational diabetes mellitus in Chinese women
por: Huang, Chengjing, et al.
Publicado: (2023)

Cell-Type Composition Affects Adipose Gene Expression Associations With Cardiometabolic Traits
por: Brotman, Sarah M., et al.
Publicado: (2023)

Immunoproteomic Profiling of Antiviral Antibodies in New-Onset Type 1 Diabetes Using Protein Arrays
por: Bian, Xiaofang, et al.
Publicado: (2016)

Protein Biomarkers for Insulin Resistance and Type 2 Diabetes Risk in Two Large Community Cohorts
por: Nowak, Christoph, et al.
Publicado: (2016)

Plasma protein N-glycosylation is associated with cardiovascular disease, nephropathy, and retinopathy in type 2 diabetes
por: Memarian, Elham, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_c32d62tes1ss9oc72g7fc3l7s7