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Islet β-Cell Endoplasmic Reticulum Stress Precedes the Onset of Type 1 Diabetes in the Nonobese Diabetic Mouse Model

Type 1 diabetes is preceded by islet β-cell dysfunction, but the mechanisms leading to β-cell dysfunction have not been rigorously studied. Because immune cell infiltration occurs prior to overt diabetes, we hypothesized that activation of inflammatory cascades and appearance of endoplasmic reticulu...

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Detalles Bibliográficos
Autores principales:	Tersey, Sarah A., Nishiki, Yurika, Templin, Andrew T., Cabrera, Susanne M., Stull, Natalie D., Colvin, Stephanie C., Evans-Molina, Carmella, Rickus, Jenna L., Maier, Bernhard, Mirmira, Raghavendra G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2012
Materias:	Islet Studies
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314371/ https://www.ncbi.nlm.nih.gov/pubmed/22442300 http://dx.doi.org/10.2337/db11-1293

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