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Antitumor activities of ATP-competitive inhibitors of mTOR in colon cancer cells

BACKGROUND: The mammalian target of rapamycin (mTOR) is frequently activated in colon cancers due to mutations in the phosphatidylinositol 3-kinase (PI3K) pathway. Targeting mTOR with allosteric inhibitors of mTOR such as rapamycin reduces colon cancer progression in several experimental models. Rec...

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Detalles Bibliográficos
Autores principales:	Blaser, Benjamin, Waselle, Laurent, Dormond-Meuwly, Anne, Dufour, Marc, Roulin, Didier, Demartines, Nicolas, Dormond, Olivier
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314574/ https://www.ncbi.nlm.nih.gov/pubmed/22401294 http://dx.doi.org/10.1186/1471-2407-12-86

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