No Evidence for Infection of UK Prostate Cancer Patients with XMRV, BK Virus, Trichomonas vaginalis or Human Papilloma Viruses

The prevalence of specific infections in UK prostate cancer patients was investigated. Serum from 84 patients and 62 controls was tested for neutralisation of xenotropic murine leukaemia virus-related virus (XMRV) Envelope. No reactivity was found in the patient samples. In addition, a further 100 p...

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Detalles Bibliográficos
Autores principales: Groom, Harriet C. T., Warren, Anne Y., Neal, David E., Bishop, Kate N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314598/
https://www.ncbi.nlm.nih.gov/pubmed/22470540
http://dx.doi.org/10.1371/journal.pone.0034221
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author Groom, Harriet C. T.
Warren, Anne Y.
Neal, David E.
Bishop, Kate N.
author_facet Groom, Harriet C. T.
Warren, Anne Y.
Neal, David E.
Bishop, Kate N.
author_sort Groom, Harriet C. T.
collection PubMed
description The prevalence of specific infections in UK prostate cancer patients was investigated. Serum from 84 patients and 62 controls was tested for neutralisation of xenotropic murine leukaemia virus-related virus (XMRV) Envelope. No reactivity was found in the patient samples. In addition, a further 100 prostate DNA samples were tested for XMRV, BK virus, Trichomonas vaginalis and human papilloma viruses by nucleic acid detection techniques. Despite demonstrating DNA integrity and assay sensitivity, we failed to detect the presence of any of these agents in DNA samples, bar one sample that was weakly positive for HPV16. Therefore we conclude that these infections are absent in this typical cohort of men with prostate cancer.
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spelling pubmed-33145982012-04-02 No Evidence for Infection of UK Prostate Cancer Patients with XMRV, BK Virus, Trichomonas vaginalis or Human Papilloma Viruses Groom, Harriet C. T. Warren, Anne Y. Neal, David E. Bishop, Kate N. PLoS One Research Article The prevalence of specific infections in UK prostate cancer patients was investigated. Serum from 84 patients and 62 controls was tested for neutralisation of xenotropic murine leukaemia virus-related virus (XMRV) Envelope. No reactivity was found in the patient samples. In addition, a further 100 prostate DNA samples were tested for XMRV, BK virus, Trichomonas vaginalis and human papilloma viruses by nucleic acid detection techniques. Despite demonstrating DNA integrity and assay sensitivity, we failed to detect the presence of any of these agents in DNA samples, bar one sample that was weakly positive for HPV16. Therefore we conclude that these infections are absent in this typical cohort of men with prostate cancer. Public Library of Science 2012-03-28 /pmc/articles/PMC3314598/ /pubmed/22470540 http://dx.doi.org/10.1371/journal.pone.0034221 Text en Groom et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Groom, Harriet C. T.
Warren, Anne Y.
Neal, David E.
Bishop, Kate N.
No Evidence for Infection of UK Prostate Cancer Patients with XMRV, BK Virus, Trichomonas vaginalis or Human Papilloma Viruses
title No Evidence for Infection of UK Prostate Cancer Patients with XMRV, BK Virus, Trichomonas vaginalis or Human Papilloma Viruses
title_full No Evidence for Infection of UK Prostate Cancer Patients with XMRV, BK Virus, Trichomonas vaginalis or Human Papilloma Viruses
title_fullStr No Evidence for Infection of UK Prostate Cancer Patients with XMRV, BK Virus, Trichomonas vaginalis or Human Papilloma Viruses
title_full_unstemmed No Evidence for Infection of UK Prostate Cancer Patients with XMRV, BK Virus, Trichomonas vaginalis or Human Papilloma Viruses
title_short No Evidence for Infection of UK Prostate Cancer Patients with XMRV, BK Virus, Trichomonas vaginalis or Human Papilloma Viruses
title_sort no evidence for infection of uk prostate cancer patients with xmrv, bk virus, trichomonas vaginalis or human papilloma viruses
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314598/
https://www.ncbi.nlm.nih.gov/pubmed/22470540
http://dx.doi.org/10.1371/journal.pone.0034221
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