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Epigenetic Silencing of the Circadian Clock Gene CRY1 is Associated with an Indolent Clinical Course in Chronic Lymphocytic Leukemia
Disruption of circadian rhythm is believed to play a critical role in cancer development. Cryptochrome 1 (CRY1) is a core component of the mammalian circadian clock and we have previously shown its deregulated expression in a subgroup of patients with chronic lymphocytic leukemia (CLL). Using real-t...
Autores principales: | Hanoun, Maher, Eisele, Lewin, Suzuki, Masako, Greally, John M., Hüttmann, Andreas, Aydin, Semra, Scholtysik, René, Klein-Hitpass, Ludger, Dührsen, Ulrich, Dürig, Jan |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314606/ https://www.ncbi.nlm.nih.gov/pubmed/22470559 http://dx.doi.org/10.1371/journal.pone.0034347 |
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