Overexpression of DNA Polymerase Zeta Reduces the Mitochondrial Mutability Caused by Pathological Mutations in DNA Polymerase Gamma in Yeast

In yeast, DNA polymerase zeta (Rev3 and Rev7) and Rev1, involved in the error-prone translesion synthesis during replication of nuclear DNA, localize also in mitochondria. We show that overexpression of Rev3 reduced the mtDNA extended mutability caused by a subclass of pathological mutations in Mip1...

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Detalles Bibliográficos
Autores principales: Baruffini, Enrico, Serafini, Fausta, Ferrero, Iliana, Lodi, Tiziana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314619/
https://www.ncbi.nlm.nih.gov/pubmed/22470557
http://dx.doi.org/10.1371/journal.pone.0034322

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