Internalization of Modified Lipids by CD36 and SR-A Leads to Hepatic Inflammation and Lysosomal Cholesterol Storage in Kupffer Cells

BACKGROUND & AIMS: Non-alcoholic steatohepatitis (NASH) is characterized by steatosis and inflammation, which can further progress into fibrosis and cirrhosis. Recently, we demonstrated that combined deletion of the two main scavenger receptors, CD36 and macrophage scavenger receptor 1 (MSR1), w...

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Detalles Bibliográficos
Autores principales: Bieghs, Veerle, Verheyen, Fons, van Gorp, Patrick J., Hendrikx, Tim, Wouters, Kristiaan, Lütjohann, Dieter, Gijbels, Marion J. J., Febbraio, Maria, Binder, Christoph J., Hofker, Marten H., Shiri-Sverdlov, Ronit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314620/
https://www.ncbi.nlm.nih.gov/pubmed/22470565
http://dx.doi.org/10.1371/journal.pone.0034378

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314620/
https://www.ncbi.nlm.nih.gov/pubmed/22470565
http://dx.doi.org/10.1371/journal.pone.0034378

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