Cargando…

Internalization of Modified Lipids by CD36 and SR-A Leads to Hepatic Inflammation and Lysosomal Cholesterol Storage in Kupffer Cells

BACKGROUND & AIMS: Non-alcoholic steatohepatitis (NASH) is characterized by steatosis and inflammation, which can further progress into fibrosis and cirrhosis. Recently, we demonstrated that combined deletion of the two main scavenger receptors, CD36 and macrophage scavenger receptor 1 (MSR1), w...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bieghs, Veerle, Verheyen, Fons, van Gorp, Patrick J., Hendrikx, Tim, Wouters, Kristiaan, Lütjohann, Dieter, Gijbels, Marion J. J., Febbraio, Maria, Binder, Christoph J., Hofker, Marten H., Shiri-Sverdlov, Ronit
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314620/ https://www.ncbi.nlm.nih.gov/pubmed/22470565 http://dx.doi.org/10.1371/journal.pone.0034378

Ejemplares similares

LDL Receptor Knock-Out Mice Are a Physiological Model Particularly Vulnerable to Study the Onset of Inflammation in Non-Alcoholic Fatty Liver Disease
por: Bieghs, Veerle, et al.
Publicado: (2012)

Blood-derived macrophages prone to accumulate lysosomal lipids trigger oxLDL-dependent murine hepatic inflammation
por: Houben, Tom, et al.
Publicado: (2017)

Macrophage Specific Caspase-1/11 Deficiency Protects against Cholesterol Crystallization and Hepatic Inflammation in Hyperlipidemic Mice
por: Hendrikx, Tim, et al.
Publicado: (2013)

Cathepsin D regulates lipid metabolism in murine steatohepatitis
por: Houben, Tom, et al.
Publicado: (2017)

Neutrophil-Derived Myeloperoxidase Aggravates Non-Alcoholic Steatohepatitis in Low-Density Lipoprotein Receptor-Deficient Mice
por: Rensen, Sander S., et al.
Publicado: (2012)

Plasma cathepsin D correlates with histological classifications of fatty liver disease in adults and responds to intervention
por: Walenbergh, Sofie M. A., et al.
Publicado: (2016)

Weekly Treatment of 2-Hydroxypropyl-β-cyclodextrin Improves Intracellular Cholesterol Levels in LDL Receptor Knockout Mice
por: Walenbergh, Sofie M. A., et al.
Publicado: (2015)

Anti-Inflammatory Effects of Dietary Plant Stanol Supplementation Are Largely Dependent on the Intake of Cholesterol in a Mouse Model of Metabolic Inflammation
por: Magro dos Reis, Inês, et al.
Publicado: (2021)

Protective Role of Plant Sterol and Stanol Esters in Liver Inflammation: Insights from Mice and Humans
por: Plat, Jogchum, et al.
Publicado: (2014)

Pneumococcal Immunization Reduces Neurological and Hepatic Symptoms in a Mouse Model for Niemann-Pick Type C1 Disease
por: Houben, Tom, et al.
Publicado: (2019)

Polymorphisms of the TUB Gene Are Associated with Body Composition and Eating Behavior in Middle-Aged Women
por: van Vliet-Ostaptchouk, Jana V., et al.
Publicado: (2008)

Myeloid DLL4 Does Not Contribute to the Pathogenesis of Non-Alcoholic Steatohepatitis in Ldlr(-/-) Mice
por: Jeurissen, Mike L. J., et al.
Publicado: (2016)

Low levels of IgM antibodies recognizing oxidation-specific epitopes are associated with human non-alcoholic fatty liver disease
por: Hendrikx, Tim, et al.
Publicado: (2016)

Inhibition of Extracellular Cathepsin D Reduces Hepatic Lipid Accumulation and Leads to Mild Changes in Inflammationin NASH Mice
por: Yadati, Tulasi, et al.
Publicado: (2021)

Pro-Inflammatory Implications of 2-Hydroxypropyl-β-cyclodextrin Treatment
por: Houben, Tom, et al.
Publicado: (2021)

Sialic Acid-Binding Immunoglobulin-like Lectin G Promotes Atherosclerosis and Liver Inflammation by Suppressing the Protective Functions of B-1 Cells
por: Gruber, Sabrina, et al.
Publicado: (2016)

Macrophage Stimulating Protein Enhances Hepatic Inflammation in a NASH Model
por: Li, Jieyi, et al.
Publicado: (2016)

Hematopoietic Npc1 mutation shifts gut microbiota composition in Ldlr(−/−) mice on a high-fat, high-cholesterol diet
por: Houben, Tom, et al.
Publicado: (2019)

Comment on Tauriainen et al.: Serum, liver and bile sitosterol and sitostanol in obese patients with and without NAFLD
por: Plat, Jogchum, et al.
Publicado: (2018)

NAFLD Preclinical Models: More than a Handful, Less of a Concern?
por: Oligschlaeger, Yvonne, et al.
Publicado: (2020)

NASH and Systemic Complications: From Basic to Clinical Research
por: Baumgartner, Sabine, et al.
Publicado: (2021)

The Influence of a Conjugated Pneumococcal Vaccination on Plasma Antibody Levels against Oxidized Low-Density Lipoprotein in Metabolic Disease Patients: A Single-Arm Pilot Clinical Trial
por: Shiri-Sverdlov, Ronit, et al.
Publicado: (2021)

Cholesterol-Induced Hepatic Inflammation Does Not Underlie the Predisposition to Insulin Resistance in Dyslipidemic Female LDL Receptor Knockout Mice
por: Gruben, Nanda, et al.
Publicado: (2015)

Oxidized LDL in Inflammation: From Bench to Bedside
por: Tekin, Ishak Ozel, et al.
Publicado: (2013)

CD36/SR-B2-TLR2 Dependent Pathways Enhance Porphyromonas gingivalis Mediated Atherosclerosis in the Ldlr KO Mouse Model
por: Brown, Paul M., et al.
Publicado: (2015)

Kupffer Cells in Health and Disease
por: Woltman, Andrea M., et al.
Publicado: (2014)

COVID‐19 infection, progression, and vaccination: Focus on obesity and related metabolic disturbances
por: Westheim, Annemarie J. F., et al.
Publicado: (2021)

Mediators of Gut Mucosal Immunity and Inflammation
por: Tekin, Ishak Ozel, et al.
Publicado: (2015)

The Ins and Outs of Cathepsins: Physiological Function and Role in Disease Management
por: Yadati, Tulasi, et al.
Publicado: (2020)

Effect of Interferon Gamma on Ebola Virus Infection of Primary Kupffer Cells and a Kupffer Cell Line
por: Aguilar-Briseño, José A., et al.
Publicado: (2023)

THE CHARACTERS OF KUPFFER CELLS LIVING IN VITRO
por: Beard, J. W., et al.
Publicado: (1934)

Three-dimensional flow in Kupffer’s Vesicle
por: Montenegro-Johnson, T. D., et al.
Publicado: (2016)

Kupffer cells in hepatotoxicity
por: Hassan, Reham
Publicado: (2020)

TFEB-lysosome pathway activation is associated with different cell death responses to carbon quantum dots in Kupffer cells and hepatocytes
por: Pang, Yanting, et al.
Publicado: (2022)

Sex‐opposed inflammatory effects of 27‐hydroxycholesterol are mediated via differences in estrogen signaling
por: Houben, Tom, et al.
Publicado: (2020)

Effect of Kupffer cells depletion on ABC phenomenon induced by Kupffer cells-targeted liposomes
por: Lai, Chaoyang, et al.
Publicado: (2019)

Characterization of Kupffer cells in livers of developing mice
por: Lopez, Bryan G, et al.
Publicado: (2011)

Shp2 Deficiency in Kupffer Cells and Hepatocytes Aggravates Hepatocarcinogenesis by Recruiting Non-Kupffer Macrophages
por: Du, Li, et al.
Publicado: (2023)

All Roads Lead to Cathepsins: The Role of Cathepsins in Non-Alcoholic Steatohepatitis-Induced Hepatocellular Carcinoma
por: van Mourik, Hester, et al.
Publicado: (2022)

Loss of lysosomal membrane protein NCU-G1 in mice results in spontaneous liver fibrosis with accumulation of lipofuscin and iron in Kupffer cells
por: Kong, Xiang Y., et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_kfndh2153abd94q83t0tnrnfpl