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Systemic Treatment with CpG-B after Sublethal Rickettsial Infection Induces Mouse Death through Indoleamine 2,3-Dioxygenase (IDO)

Due to its strong immune stimulatory effects through TLR9, CpG-containing oligodeoxynucleotides (CpG ODN) have been tested in multiple clinical trials as vaccine adjuvant for infectious diseases and cancer. However, immune suppression induced by systemic administration of CpGs has been reported rece...

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Detalles Bibliográficos
Autores principales:	Xin, Lijun, Shelite, Thomas R., Gong, Bin, Mendell, Nicole L., Soong, Lynn, Fang, Rong, Walker, David H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314704/ https://www.ncbi.nlm.nih.gov/pubmed/22470514 http://dx.doi.org/10.1371/journal.pone.0034062

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