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Quantification of iron concentration in the liver by MRI

OBJECTIVE: Measurement of liver iron concentration is a key parameter for the management of patients with primary and secondary haemochromatosis. Magnetic resonance imaging (MRI) has already demonstrated high accuracy to quantify liver iron content. To be able to improve the current management of pa...

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Autores principales: Alústiza Echeverría, José María, Castiella, Agustín, Emparanza, José Ignacio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314738/
https://www.ncbi.nlm.nih.gov/pubmed/22696043
http://dx.doi.org/10.1007/s13244-011-0132-1
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author Alústiza Echeverría, José María
Castiella, Agustín
Emparanza, José Ignacio
author_facet Alústiza Echeverría, José María
Castiella, Agustín
Emparanza, José Ignacio
author_sort Alústiza Echeverría, José María
collection PubMed
description OBJECTIVE: Measurement of liver iron concentration is a key parameter for the management of patients with primary and secondary haemochromatosis. Magnetic resonance imaging (MRI) has already demonstrated high accuracy to quantify liver iron content. To be able to improve the current management of patients that are found to have iron overload, we need a reproducible, standardised method that is, or can easily be made, widely available. METHODS: This article discusses the different MRI techniques and models to quantify liver iron concentration that are currently available and envisaged for the near future from a realistic perspective. RESULTS: T2 relaxometry methods are more accurate than signal intensity ratio (SIR) methods and they are reproducible but are not yet standardised or widely available. SIR methods, on the other hand, are very specific for all levels of iron overload and, what is more, they are also reproducible, standardised and already widely available. CONCLUSIONS: For these reasons, today, both methods remain necessary while progress is made towards universal standardisation of the relaxometry technique.
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spelling pubmed-33147382012-04-05 Quantification of iron concentration in the liver by MRI Alústiza Echeverría, José María Castiella, Agustín Emparanza, José Ignacio Insights Imaging Review OBJECTIVE: Measurement of liver iron concentration is a key parameter for the management of patients with primary and secondary haemochromatosis. Magnetic resonance imaging (MRI) has already demonstrated high accuracy to quantify liver iron content. To be able to improve the current management of patients that are found to have iron overload, we need a reproducible, standardised method that is, or can easily be made, widely available. METHODS: This article discusses the different MRI techniques and models to quantify liver iron concentration that are currently available and envisaged for the near future from a realistic perspective. RESULTS: T2 relaxometry methods are more accurate than signal intensity ratio (SIR) methods and they are reproducible but are not yet standardised or widely available. SIR methods, on the other hand, are very specific for all levels of iron overload and, what is more, they are also reproducible, standardised and already widely available. CONCLUSIONS: For these reasons, today, both methods remain necessary while progress is made towards universal standardisation of the relaxometry technique. Springer-Verlag 2011-12-30 /pmc/articles/PMC3314738/ /pubmed/22696043 http://dx.doi.org/10.1007/s13244-011-0132-1 Text en © European Society of Radiology 2011
spellingShingle Review
Alústiza Echeverría, José María
Castiella, Agustín
Emparanza, José Ignacio
Quantification of iron concentration in the liver by MRI
title Quantification of iron concentration in the liver by MRI
title_full Quantification of iron concentration in the liver by MRI
title_fullStr Quantification of iron concentration in the liver by MRI
title_full_unstemmed Quantification of iron concentration in the liver by MRI
title_short Quantification of iron concentration in the liver by MRI
title_sort quantification of iron concentration in the liver by mri
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314738/
https://www.ncbi.nlm.nih.gov/pubmed/22696043
http://dx.doi.org/10.1007/s13244-011-0132-1
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