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Relation between Anemia and Vulnerable Coronary Plaque Components in Patients with Acute Coronary Syndrome: Virtual Histology-Intravascular Ultrasound Analysis
The aim of the present study was to evaluate the plaque components and the predictors of thin-cap fibroatheroma (TCFA) in anemic patients with acute coronary syndrome using virtual histology-intravascular ultrasound (VH-IVUS). Anemia was defined according to criteria of the World Health Organization...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Academy of Medical Sciences
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314848/ https://www.ncbi.nlm.nih.gov/pubmed/22468099 http://dx.doi.org/10.3346/jkms.2012.27.4.370 |
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author | Hong, Young Joon Jeong, Myung Ho Choi, Yun Ha Song, Jin A Kim, Dong Han Lee, Ki Hong Yamanaka, Futoshi Lee, Min Goo Park, Keun Ho Sim, Doo Sun Yoon, Nam Sik Yoon, Hyun Ju Kim, Kye Hun Park, Hyung Wook Kim, Ju Han Ahn, Youngkeun Cho, Jeong Gwan Park, Jong Chun Kang, Jung Chaee |
author_facet | Hong, Young Joon Jeong, Myung Ho Choi, Yun Ha Song, Jin A Kim, Dong Han Lee, Ki Hong Yamanaka, Futoshi Lee, Min Goo Park, Keun Ho Sim, Doo Sun Yoon, Nam Sik Yoon, Hyun Ju Kim, Kye Hun Park, Hyung Wook Kim, Ju Han Ahn, Youngkeun Cho, Jeong Gwan Park, Jong Chun Kang, Jung Chaee |
author_sort | Hong, Young Joon |
collection | PubMed |
description | The aim of the present study was to evaluate the plaque components and the predictors of thin-cap fibroatheroma (TCFA) in anemic patients with acute coronary syndrome using virtual histology-intravascular ultrasound (VH-IVUS). Anemia was defined according to criteria of the World Health Organization, (i.e. , hemoglobin levels < 13 g/dL in men and < 12 g/dL in women) and we compared VH-IVUS findings between anemia group (171 patients, 260 lesions) and non-anemia group (569 patients, 881 lesions). Anemia group had greater % necrotic core (NC) volume (21% ± 9% vs 19% ± 9%, P = 0.001) compared with non-anemia group. Hemoglobin level correlated negatively with absolute NC volume (r = -0.235, P < 0.001) and %NC volume (r = -0.209, P < 0.001). Independent predictors of TCFA by multivariate analysis were diabetes mellitus (odds ratio [OR], 2.213; 95% confidence interval [CI], 1.403-3.612, P = 0.006), high-sensitivity C-reactive protein (OR, 1.143; 95% CI, 1.058-1.304, P = 0.012), microalbuminuria (albumin levels of 30 to 300 mg/g of creatinine) (OR, 2.124; 95% CI, 1.041-3.214, P = 0.018), and anemia (OR: 2.112; 95% CI 1.022-3.208, P = 0.028). VH-IVUS analysis demonstrates that anemia at the time of clinical presentation is associated with vulnerable plaque component in patients with acute coronary syndrome. |
format | Online Article Text |
id | pubmed-3314848 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | The Korean Academy of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-33148482012-04-01 Relation between Anemia and Vulnerable Coronary Plaque Components in Patients with Acute Coronary Syndrome: Virtual Histology-Intravascular Ultrasound Analysis Hong, Young Joon Jeong, Myung Ho Choi, Yun Ha Song, Jin A Kim, Dong Han Lee, Ki Hong Yamanaka, Futoshi Lee, Min Goo Park, Keun Ho Sim, Doo Sun Yoon, Nam Sik Yoon, Hyun Ju Kim, Kye Hun Park, Hyung Wook Kim, Ju Han Ahn, Youngkeun Cho, Jeong Gwan Park, Jong Chun Kang, Jung Chaee J Korean Med Sci Original Article The aim of the present study was to evaluate the plaque components and the predictors of thin-cap fibroatheroma (TCFA) in anemic patients with acute coronary syndrome using virtual histology-intravascular ultrasound (VH-IVUS). Anemia was defined according to criteria of the World Health Organization, (i.e. , hemoglobin levels < 13 g/dL in men and < 12 g/dL in women) and we compared VH-IVUS findings between anemia group (171 patients, 260 lesions) and non-anemia group (569 patients, 881 lesions). Anemia group had greater % necrotic core (NC) volume (21% ± 9% vs 19% ± 9%, P = 0.001) compared with non-anemia group. Hemoglobin level correlated negatively with absolute NC volume (r = -0.235, P < 0.001) and %NC volume (r = -0.209, P < 0.001). Independent predictors of TCFA by multivariate analysis were diabetes mellitus (odds ratio [OR], 2.213; 95% confidence interval [CI], 1.403-3.612, P = 0.006), high-sensitivity C-reactive protein (OR, 1.143; 95% CI, 1.058-1.304, P = 0.012), microalbuminuria (albumin levels of 30 to 300 mg/g of creatinine) (OR, 2.124; 95% CI, 1.041-3.214, P = 0.018), and anemia (OR: 2.112; 95% CI 1.022-3.208, P = 0.028). VH-IVUS analysis demonstrates that anemia at the time of clinical presentation is associated with vulnerable plaque component in patients with acute coronary syndrome. The Korean Academy of Medical Sciences 2012-04 2012-03-21 /pmc/articles/PMC3314848/ /pubmed/22468099 http://dx.doi.org/10.3346/jkms.2012.27.4.370 Text en © 2012 The Korean Academy of Medical Sciences. http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Hong, Young Joon Jeong, Myung Ho Choi, Yun Ha Song, Jin A Kim, Dong Han Lee, Ki Hong Yamanaka, Futoshi Lee, Min Goo Park, Keun Ho Sim, Doo Sun Yoon, Nam Sik Yoon, Hyun Ju Kim, Kye Hun Park, Hyung Wook Kim, Ju Han Ahn, Youngkeun Cho, Jeong Gwan Park, Jong Chun Kang, Jung Chaee Relation between Anemia and Vulnerable Coronary Plaque Components in Patients with Acute Coronary Syndrome: Virtual Histology-Intravascular Ultrasound Analysis |
title | Relation between Anemia and Vulnerable Coronary Plaque Components in Patients with Acute Coronary Syndrome: Virtual Histology-Intravascular Ultrasound Analysis |
title_full | Relation between Anemia and Vulnerable Coronary Plaque Components in Patients with Acute Coronary Syndrome: Virtual Histology-Intravascular Ultrasound Analysis |
title_fullStr | Relation between Anemia and Vulnerable Coronary Plaque Components in Patients with Acute Coronary Syndrome: Virtual Histology-Intravascular Ultrasound Analysis |
title_full_unstemmed | Relation between Anemia and Vulnerable Coronary Plaque Components in Patients with Acute Coronary Syndrome: Virtual Histology-Intravascular Ultrasound Analysis |
title_short | Relation between Anemia and Vulnerable Coronary Plaque Components in Patients with Acute Coronary Syndrome: Virtual Histology-Intravascular Ultrasound Analysis |
title_sort | relation between anemia and vulnerable coronary plaque components in patients with acute coronary syndrome: virtual histology-intravascular ultrasound analysis |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314848/ https://www.ncbi.nlm.nih.gov/pubmed/22468099 http://dx.doi.org/10.3346/jkms.2012.27.4.370 |
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