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Serum Glutathione S-Transferase P1 1 in Prediction of Cardiac Function
BACKGROUND: Glutathione S-transferase P1 1 (GSTP1) belongs to the multigene isozyme family involved in cellular response to oxidative stress and apoptosis. Our initial retrospective proteomic analysis suggested that GSTP1 is associated with heart failure (HF). Although pro–B-type natriuretic peptide...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Churchill Livingstone
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314906/ https://www.ncbi.nlm.nih.gov/pubmed/22385947 http://dx.doi.org/10.1016/j.cardfail.2011.11.003 |
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author | Andrukhova, Olena Salama, Mohamed Rosenhek, Raphael Gmeiner, Matthias Perkmann, Thomas Steindl, Johannes Aharinejad, Seyedhossein |
author_facet | Andrukhova, Olena Salama, Mohamed Rosenhek, Raphael Gmeiner, Matthias Perkmann, Thomas Steindl, Johannes Aharinejad, Seyedhossein |
author_sort | Andrukhova, Olena |
collection | PubMed |
description | BACKGROUND: Glutathione S-transferase P1 1 (GSTP1) belongs to the multigene isozyme family involved in cellular response to oxidative stress and apoptosis. Our initial retrospective proteomic analysis suggested that GSTP1 is associated with heart failure (HF). Although pro–B-type natriuretic peptide (proBNP) serves currently as a surrogate diagnostic and prognostic parameter in HF patients, its specificity remains uncertain. We hypothesized that GSTP1 might be a useful serum marker in the monitoring of HF patients. METHODS AND RESULTS: Serum GSTP1 and proBNP were prospectively measured in 193 patients subdivided based on their ejection fraction (EF) either in equal-sized quintiles or predefined EF groups >52%, 43%–52%, 33%–42%, 23%–32% and ≤22%. At a cutoff of ≥231 ng/mL, GSTP1 identified HF patients with EF ≤22% with 81% sensitivity and 83% specificity, and at a cutoff of ≥655 pg/mL, proBNP identified the same patient group with 84% sensitivity and 22% specificity. GSTP1 at a ≥126 ng/mL cutoff identified EF ≤42% with 90% sensitivity and 95% specificity, or proBNP at a ≥396 pg/mL cutoff had 97% sensitivity and 20% specificity. In regression analyses, GSTP1, but not proBNP, discriminated between EF ≤42% and EF >42% in HF patients. CONCLUSIONS: These results suggest that GSTP1 is strongly associated with HF and could serve as a sensitive and specific marker to predict the ventricular function in HF patients. |
format | Online Article Text |
id | pubmed-3314906 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Churchill Livingstone |
record_format | MEDLINE/PubMed |
spelling | pubmed-33149062012-04-11 Serum Glutathione S-Transferase P1 1 in Prediction of Cardiac Function Andrukhova, Olena Salama, Mohamed Rosenhek, Raphael Gmeiner, Matthias Perkmann, Thomas Steindl, Johannes Aharinejad, Seyedhossein J Card Fail Basic Science and Experimental Study BACKGROUND: Glutathione S-transferase P1 1 (GSTP1) belongs to the multigene isozyme family involved in cellular response to oxidative stress and apoptosis. Our initial retrospective proteomic analysis suggested that GSTP1 is associated with heart failure (HF). Although pro–B-type natriuretic peptide (proBNP) serves currently as a surrogate diagnostic and prognostic parameter in HF patients, its specificity remains uncertain. We hypothesized that GSTP1 might be a useful serum marker in the monitoring of HF patients. METHODS AND RESULTS: Serum GSTP1 and proBNP were prospectively measured in 193 patients subdivided based on their ejection fraction (EF) either in equal-sized quintiles or predefined EF groups >52%, 43%–52%, 33%–42%, 23%–32% and ≤22%. At a cutoff of ≥231 ng/mL, GSTP1 identified HF patients with EF ≤22% with 81% sensitivity and 83% specificity, and at a cutoff of ≥655 pg/mL, proBNP identified the same patient group with 84% sensitivity and 22% specificity. GSTP1 at a ≥126 ng/mL cutoff identified EF ≤42% with 90% sensitivity and 95% specificity, or proBNP at a ≥396 pg/mL cutoff had 97% sensitivity and 20% specificity. In regression analyses, GSTP1, but not proBNP, discriminated between EF ≤42% and EF >42% in HF patients. CONCLUSIONS: These results suggest that GSTP1 is strongly associated with HF and could serve as a sensitive and specific marker to predict the ventricular function in HF patients. Churchill Livingstone 2012-03 /pmc/articles/PMC3314906/ /pubmed/22385947 http://dx.doi.org/10.1016/j.cardfail.2011.11.003 Text en © 2012 Elsevier Inc. https://creativecommons.org/licenses/by-nc-nd/3.0/ Open Access under CC BY-NC-ND 3.0 (https://creativecommons.org/licenses/by-nc-nd/3.0/) license |
spellingShingle | Basic Science and Experimental Study Andrukhova, Olena Salama, Mohamed Rosenhek, Raphael Gmeiner, Matthias Perkmann, Thomas Steindl, Johannes Aharinejad, Seyedhossein Serum Glutathione S-Transferase P1 1 in Prediction of Cardiac Function |
title | Serum Glutathione S-Transferase P1 1 in Prediction of Cardiac Function |
title_full | Serum Glutathione S-Transferase P1 1 in Prediction of Cardiac Function |
title_fullStr | Serum Glutathione S-Transferase P1 1 in Prediction of Cardiac Function |
title_full_unstemmed | Serum Glutathione S-Transferase P1 1 in Prediction of Cardiac Function |
title_short | Serum Glutathione S-Transferase P1 1 in Prediction of Cardiac Function |
title_sort | serum glutathione s-transferase p1 1 in prediction of cardiac function |
topic | Basic Science and Experimental Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314906/ https://www.ncbi.nlm.nih.gov/pubmed/22385947 http://dx.doi.org/10.1016/j.cardfail.2011.11.003 |
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