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Diffusion tractography of post-mortem human brains: Optimization and comparison of spin echo and steady-state free precession techniques
Diffusion imaging of post-mortem brains could provide valuable data for validation of diffusion tractography of white matter pathways. Long scans (e.g., overnight) may also enable high-resolution diffusion images for visualization of fine structures. However, alterations to post-mortem tissue (T2 an...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Academic Press
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314951/ https://www.ncbi.nlm.nih.gov/pubmed/22008372 http://dx.doi.org/10.1016/j.neuroimage.2011.09.054 |
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author | Miller, Karla L. McNab, Jennifer A. Jbabdi, Saad Douaud, Gwenaëlle |
author_facet | Miller, Karla L. McNab, Jennifer A. Jbabdi, Saad Douaud, Gwenaëlle |
author_sort | Miller, Karla L. |
collection | PubMed |
description | Diffusion imaging of post-mortem brains could provide valuable data for validation of diffusion tractography of white matter pathways. Long scans (e.g., overnight) may also enable high-resolution diffusion images for visualization of fine structures. However, alterations to post-mortem tissue (T2 and diffusion coefficient) present significant challenges to diffusion imaging with conventional diffusion-weighted spin echo (DW-SE) acquisitions, particularly for imaging human brains on clinical scanners. Diffusion-weighted steady-state free precession (DW-SSFP) has been proposed as an alternative acquisition technique to ameliorate this tradeoff in large-bore clinical scanners. In this study, both DWSE and DW-SSFP are optimized for use in fixed white matter on a clinical 3-Tesla scanner. Signal calculations predict superior performance from DW-SSFP across a broad range of protocols and conditions. DW-SE and DW-SSFP data in a whole, post-mortem human brain are compared for 6- and 12-hour scan durations. Tractography is performed in major projection, commissural and association tracts (corticospinal tract, corpus callosum, superior longitudinal fasciculus and cingulum bundle). The results demonstrate superior tract-tracing from DW-SSFP data, with 6-hour DW-SSFP data performing as well as or better than 12-hour DW-SE scans. These results suggest that DW-SSFP may be a preferred method for diffusion imaging of post-mortem human brains. The ability to estimate multiple fibers in imaging voxels is also demonstrated, again with greater success in DW-SSFP data. |
format | Online Article Text |
id | pubmed-3314951 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Academic Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-33149512012-04-11 Diffusion tractography of post-mortem human brains: Optimization and comparison of spin echo and steady-state free precession techniques Miller, Karla L. McNab, Jennifer A. Jbabdi, Saad Douaud, Gwenaëlle Neuroimage Article Diffusion imaging of post-mortem brains could provide valuable data for validation of diffusion tractography of white matter pathways. Long scans (e.g., overnight) may also enable high-resolution diffusion images for visualization of fine structures. However, alterations to post-mortem tissue (T2 and diffusion coefficient) present significant challenges to diffusion imaging with conventional diffusion-weighted spin echo (DW-SE) acquisitions, particularly for imaging human brains on clinical scanners. Diffusion-weighted steady-state free precession (DW-SSFP) has been proposed as an alternative acquisition technique to ameliorate this tradeoff in large-bore clinical scanners. In this study, both DWSE and DW-SSFP are optimized for use in fixed white matter on a clinical 3-Tesla scanner. Signal calculations predict superior performance from DW-SSFP across a broad range of protocols and conditions. DW-SE and DW-SSFP data in a whole, post-mortem human brain are compared for 6- and 12-hour scan durations. Tractography is performed in major projection, commissural and association tracts (corticospinal tract, corpus callosum, superior longitudinal fasciculus and cingulum bundle). The results demonstrate superior tract-tracing from DW-SSFP data, with 6-hour DW-SSFP data performing as well as or better than 12-hour DW-SE scans. These results suggest that DW-SSFP may be a preferred method for diffusion imaging of post-mortem human brains. The ability to estimate multiple fibers in imaging voxels is also demonstrated, again with greater success in DW-SSFP data. Academic Press 2012-02-01 /pmc/articles/PMC3314951/ /pubmed/22008372 http://dx.doi.org/10.1016/j.neuroimage.2011.09.054 Text en © 2012 Elsevier Inc. https://creativecommons.org/licenses/by/3.0/ Open Access under CC BY 3.0 (https://creativecommons.org/licenses/by/3.0/) license |
spellingShingle | Article Miller, Karla L. McNab, Jennifer A. Jbabdi, Saad Douaud, Gwenaëlle Diffusion tractography of post-mortem human brains: Optimization and comparison of spin echo and steady-state free precession techniques |
title | Diffusion tractography of post-mortem human brains: Optimization and comparison of spin echo and steady-state free precession techniques |
title_full | Diffusion tractography of post-mortem human brains: Optimization and comparison of spin echo and steady-state free precession techniques |
title_fullStr | Diffusion tractography of post-mortem human brains: Optimization and comparison of spin echo and steady-state free precession techniques |
title_full_unstemmed | Diffusion tractography of post-mortem human brains: Optimization and comparison of spin echo and steady-state free precession techniques |
title_short | Diffusion tractography of post-mortem human brains: Optimization and comparison of spin echo and steady-state free precession techniques |
title_sort | diffusion tractography of post-mortem human brains: optimization and comparison of spin echo and steady-state free precession techniques |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314951/ https://www.ncbi.nlm.nih.gov/pubmed/22008372 http://dx.doi.org/10.1016/j.neuroimage.2011.09.054 |
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