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COMT Val(158)Met Genotype Determines the Direction of Cognitive Effects Produced by Catechol-O-Methyltransferase Inhibition

BACKGROUND: Catechol-O-methyltransferase (COMT) metabolizes dopamine. The COMT Val(158)Met polymorphism influences its activity, and multiple neural correlates of this genotype on dopaminergic phenotypes, especially working memory, have been reported. COMT activity can also be regulated pharmacologi...

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Detalles Bibliográficos
Autores principales:	Farrell, Sarah M., Tunbridge, Elizabeth M., Braeutigam, Sven, Harrison, Paul J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2012
Materias:	Archival Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314969/ https://www.ncbi.nlm.nih.gov/pubmed/22364739 http://dx.doi.org/10.1016/j.biopsych.2011.12.023

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