Opposing Functions of the ETS Factor Family Define Shh Spatial Expression in Limb Buds and Underlie Polydactyly

Sonic hedgehog (Shh) expression during limb development is crucial for specifying the identity and number of digits. The spatial pattern of Shh expression is restricted to a region called the zone of polarizing activity (ZPA), and this expression is controlled from a long distance by the cis-regulat...

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Detalles Bibliográficos
Autores principales: Lettice, Laura A., Williamson, Iain, Wiltshire, John H., Peluso, Silvia, Devenney, Paul S., Hill, Alison E., Essafi, Abdelkader, Hagman, James, Mort, Richard, Grimes, Graeme, DeAngelis, Carlo L., Hill, Robert E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2012
Materias:
Short Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314984/
https://www.ncbi.nlm.nih.gov/pubmed/22340503
http://dx.doi.org/10.1016/j.devcel.2011.12.010

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