Searching for novel anti-myotonic agents: Pharmacophore requirement for use-dependent block of skeletal muscle sodium channels by N-benzylated cyclic derivatives of tocainide

Drug screening on sodium currents of native myofibers by means of voltage-clamp recordings is predictive of pre-clinical anti-myotonic activity in vivo and ex vivo. By this approach we identified the N-benzylated beta-proline derivative of tocainide (To10) as the most potent use-dependent blocker of...

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Detalles Bibliográficos
Autores principales: De Luca, Annamaria, De Bellis, Michela, Corbo, Filomena, Franchini, Carlo, Muraglia, Marilena, Catalano, Alessia, Carocci, Alessia, Conte Camerino, Diana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pergamon Press 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314985/
https://www.ncbi.nlm.nih.gov/pubmed/21802953
http://dx.doi.org/10.1016/j.nmd.2011.07.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314985/
https://www.ncbi.nlm.nih.gov/pubmed/21802953
http://dx.doi.org/10.1016/j.nmd.2011.07.001

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