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Nuclear hormone receptor co-repressors: Structure and function
Co-repressor proteins, such as SMRT and NCoR, mediate the repressive activity of unliganded nuclear receptors and other transcription factors. They appear to act as intrinsically disordered “hub proteins” that integrate the activities of a range of transcription factors with a number of histone modi...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
North Holland Publishing
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315023/ https://www.ncbi.nlm.nih.gov/pubmed/21925568 http://dx.doi.org/10.1016/j.mce.2011.08.033 |
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author | Watson, Peter J. Fairall, Louise Schwabe, John W.R. |
author_facet | Watson, Peter J. Fairall, Louise Schwabe, John W.R. |
author_sort | Watson, Peter J. |
collection | PubMed |
description | Co-repressor proteins, such as SMRT and NCoR, mediate the repressive activity of unliganded nuclear receptors and other transcription factors. They appear to act as intrinsically disordered “hub proteins” that integrate the activities of a range of transcription factors with a number of histone modifying enzymes. Although these co-repressor proteins are challenging targets for structural studies due to their largely unstructured character, a number of structures have recently been determined of co-repressor interaction regions in complex with their interacting partners. These have yielded considerable insight into the mechanism of assembly of these complexes, the structural basis for the specificity of the interactions and also open opportunities for targeting these interactions therapeutically. |
format | Online Article Text |
id | pubmed-3315023 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | North Holland Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-33150232012-04-11 Nuclear hormone receptor co-repressors: Structure and function Watson, Peter J. Fairall, Louise Schwabe, John W.R. Mol Cell Endocrinol Review Co-repressor proteins, such as SMRT and NCoR, mediate the repressive activity of unliganded nuclear receptors and other transcription factors. They appear to act as intrinsically disordered “hub proteins” that integrate the activities of a range of transcription factors with a number of histone modifying enzymes. Although these co-repressor proteins are challenging targets for structural studies due to their largely unstructured character, a number of structures have recently been determined of co-repressor interaction regions in complex with their interacting partners. These have yielded considerable insight into the mechanism of assembly of these complexes, the structural basis for the specificity of the interactions and also open opportunities for targeting these interactions therapeutically. North Holland Publishing 2012-01-30 /pmc/articles/PMC3315023/ /pubmed/21925568 http://dx.doi.org/10.1016/j.mce.2011.08.033 Text en © 2012 Elsevier Ireland Ltd. https://creativecommons.org/licenses/by/3.0/ Open Access under CC BY 3.0 (https://creativecommons.org/licenses/by/3.0/) license |
spellingShingle | Review Watson, Peter J. Fairall, Louise Schwabe, John W.R. Nuclear hormone receptor co-repressors: Structure and function |
title | Nuclear hormone receptor co-repressors: Structure and function |
title_full | Nuclear hormone receptor co-repressors: Structure and function |
title_fullStr | Nuclear hormone receptor co-repressors: Structure and function |
title_full_unstemmed | Nuclear hormone receptor co-repressors: Structure and function |
title_short | Nuclear hormone receptor co-repressors: Structure and function |
title_sort | nuclear hormone receptor co-repressors: structure and function |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315023/ https://www.ncbi.nlm.nih.gov/pubmed/21925568 http://dx.doi.org/10.1016/j.mce.2011.08.033 |
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