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Pre-eclampsia and offspring cardiovascular health: mechanistic insights from experimental studies

Pre-eclampsia is increasingly recognized as more than an isolated disease of pregnancy. Women who have had a pregnancy complicated by pre-eclampsia have a 4-fold increased risk of later cardiovascular disease. Intriguingly, the offspring of affected pregnancies also have an increased risk of higher...

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Autores principales: Davis, Esther F., Newton, Laura, Lewandowski, Adam J., Lazdam, Merzaka, Kelly, Brenda A., Kyriakou, Theodosios, Leeson, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315178/
https://www.ncbi.nlm.nih.gov/pubmed/22455350
http://dx.doi.org/10.1042/CS20110627
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author Davis, Esther F.
Newton, Laura
Lewandowski, Adam J.
Lazdam, Merzaka
Kelly, Brenda A.
Kyriakou, Theodosios
Leeson, Paul
author_facet Davis, Esther F.
Newton, Laura
Lewandowski, Adam J.
Lazdam, Merzaka
Kelly, Brenda A.
Kyriakou, Theodosios
Leeson, Paul
author_sort Davis, Esther F.
collection PubMed
description Pre-eclampsia is increasingly recognized as more than an isolated disease of pregnancy. Women who have had a pregnancy complicated by pre-eclampsia have a 4-fold increased risk of later cardiovascular disease. Intriguingly, the offspring of affected pregnancies also have an increased risk of higher blood pressure and almost double the risk of stroke in later life. Experimental approaches to identify the key features of pre-eclampsia responsible for this programming of offspring cardiovascular health, or the key biological pathways modified in the offspring, have the potential to highlight novel targets for early primary prevention strategies. As pre-eclampsia occurs in 2–5% of all pregnancies, the findings are relevant to the current healthcare of up to 3 million people in the U.K. and 15 million people in the U.S.A. In the present paper, we review the current literature that concerns potential mechanisms for adverse cardiovascular programming in offspring exposed to pre-eclampsia, considering two major areas of investigation: first, experimental models that mimic features of the in utero environment characteristic of pre-eclampsia, and secondly, how, in humans, offspring cardiovascular phenotype is altered after exposure to pre-eclampsia. We compare and contrast the findings from these two bodies of work to develop insights into the likely key pathways of relevance. The present review and analysis highlights the pivotal role of long-term changes in vascular function and identifies areas of growing interest, specifically, response to hypoxia, immune modification, epigenetics and the anti-angiogenic in utero milieu.
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spelling pubmed-33151782012-04-09 Pre-eclampsia and offspring cardiovascular health: mechanistic insights from experimental studies Davis, Esther F. Newton, Laura Lewandowski, Adam J. Lazdam, Merzaka Kelly, Brenda A. Kyriakou, Theodosios Leeson, Paul Clin Sci (Lond) Review Article Pre-eclampsia is increasingly recognized as more than an isolated disease of pregnancy. Women who have had a pregnancy complicated by pre-eclampsia have a 4-fold increased risk of later cardiovascular disease. Intriguingly, the offspring of affected pregnancies also have an increased risk of higher blood pressure and almost double the risk of stroke in later life. Experimental approaches to identify the key features of pre-eclampsia responsible for this programming of offspring cardiovascular health, or the key biological pathways modified in the offspring, have the potential to highlight novel targets for early primary prevention strategies. As pre-eclampsia occurs in 2–5% of all pregnancies, the findings are relevant to the current healthcare of up to 3 million people in the U.K. and 15 million people in the U.S.A. In the present paper, we review the current literature that concerns potential mechanisms for adverse cardiovascular programming in offspring exposed to pre-eclampsia, considering two major areas of investigation: first, experimental models that mimic features of the in utero environment characteristic of pre-eclampsia, and secondly, how, in humans, offspring cardiovascular phenotype is altered after exposure to pre-eclampsia. We compare and contrast the findings from these two bodies of work to develop insights into the likely key pathways of relevance. The present review and analysis highlights the pivotal role of long-term changes in vascular function and identifies areas of growing interest, specifically, response to hypoxia, immune modification, epigenetics and the anti-angiogenic in utero milieu. Portland Press Ltd. 2012-03-23 2012-07-01 /pmc/articles/PMC3315178/ /pubmed/22455350 http://dx.doi.org/10.1042/CS20110627 Text en © 2012 The Author(s) The author(s) has paid for this article to be freely available under the terms of the Creative Commons Attribution Non-Commercial Licence (http://creativecommons.org/licenses/by-nc/2.5/) which permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by-nc/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Davis, Esther F.
Newton, Laura
Lewandowski, Adam J.
Lazdam, Merzaka
Kelly, Brenda A.
Kyriakou, Theodosios
Leeson, Paul
Pre-eclampsia and offspring cardiovascular health: mechanistic insights from experimental studies
title Pre-eclampsia and offspring cardiovascular health: mechanistic insights from experimental studies
title_full Pre-eclampsia and offspring cardiovascular health: mechanistic insights from experimental studies
title_fullStr Pre-eclampsia and offspring cardiovascular health: mechanistic insights from experimental studies
title_full_unstemmed Pre-eclampsia and offspring cardiovascular health: mechanistic insights from experimental studies
title_short Pre-eclampsia and offspring cardiovascular health: mechanistic insights from experimental studies
title_sort pre-eclampsia and offspring cardiovascular health: mechanistic insights from experimental studies
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315178/
https://www.ncbi.nlm.nih.gov/pubmed/22455350
http://dx.doi.org/10.1042/CS20110627
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