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Structural, energetic and dynamic properties of guanine(C8)–thymine(N3) cross-links in DNA provide insights on susceptibility to nucleotide excision repair
The one-electron oxidation of guanine in DNA by carbonate radical anions, a decomposition product of peroxynitrosocarbonate which is associated with the inflammatory response, can lead to the formation of intrastrand cross-links between guanine and thymine bases [Crean et al. (Oxidation of single-st...
Autores principales: | Ding, Shuang, Kropachev, Konstantin, Cai, Yuqin, Kolbanovskiy, Marina, Durandina, Svetlana A., Liu, Zhi, Shafirovich, Vladimir, Broyde, Suse, Geacintov, Nicholas E. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315297/ https://www.ncbi.nlm.nih.gov/pubmed/22135299 http://dx.doi.org/10.1093/nar/gkr1087 |
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