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Lack of recognition by global-genome nucleotide excision repair accounts for the high mutagenicity and persistence of aristolactam-DNA adducts

Exposure to aristolochic acid (AA), a component of Aristolochia plants used in herbal remedies, is associated with chronic kidney disease and urothelial carcinomas of the upper urinary tract. Following metabolic activation, AA reacts with dA and dG residues in DNA to form aristolactam (AL)-DNA adduc...

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Detalles Bibliográficos
Autores principales:	Sidorenko, Victoria S., Yeo, Jung-Eun, Bonala, Radha R., Johnson, Francis, Schärer, Orlando D., Grollman, Arthur P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2012
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315299/ https://www.ncbi.nlm.nih.gov/pubmed/22121226 http://dx.doi.org/10.1093/nar/gkr1095

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