5′-Triphosphate-RNA-independent activation of RIG-I via RNA aptamer with enhanced antiviral activity

RIG-I is a cytosolic receptor for non-self RNA that mediates immune responses against viral infections through IFNα/β production. In an attempt to identify novel tools that modulate IFNα/β production, we used SELEX technology to screen RNA aptamers that specifically target RIG-I protein. Most of the...

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Detalles Bibliográficos
Autores principales: Hwang, Sun-Young, Sun, Hwa-Young, Lee, Kwang-Hoon, Oh, Byung-Ha, Cha, Yu Jin, Kim, Byeang Hyean, Yoo, Joo-Yeon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315321/
https://www.ncbi.nlm.nih.gov/pubmed/22127865
http://dx.doi.org/10.1093/nar/gkr1098

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