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Comprehensive homing endonuclease target site specificity profiling reveals evolutionary constraints and enables genome engineering applications

Homing endonucleases (HEs) promote the evolutionary persistence of selfish DNA elements by catalyzing element lateral transfer into new host organisms. The high site specificity of this lateral transfer reaction, termed homing, reflects both the length (14–40 bp) and the limited tolerance of target...

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Detalles Bibliográficos
Autores principales:	Li, Hui, Ulge, Umut Y., Hovde, Blake T., Doyle, Lindsey A., Monnat, Raymond J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2012
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315327/ https://www.ncbi.nlm.nih.gov/pubmed/22121229 http://dx.doi.org/10.1093/nar/gkr1072

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