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Meningeal and cortical grey matter pathology in multiple sclerosis
Although historically considered a disease primarily affecting the white matter of the central nervous system, recent pathological and imaging studies have established that cortical demyelination is common in multiple sclerosis and more extensive than previously appreciated. Subpial, intracortical a...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315403/ https://www.ncbi.nlm.nih.gov/pubmed/22397318 http://dx.doi.org/10.1186/1471-2377-12-11 |
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author | Gh Popescu, Bogdan F Lucchinetti, Claudia F |
author_facet | Gh Popescu, Bogdan F Lucchinetti, Claudia F |
author_sort | Gh Popescu, Bogdan F |
collection | PubMed |
description | Although historically considered a disease primarily affecting the white matter of the central nervous system, recent pathological and imaging studies have established that cortical demyelination is common in multiple sclerosis and more extensive than previously appreciated. Subpial, intracortical and leukocortical lesions are the three cortical lesion types described in the cerebral and cerebellar cortices of patients with multiple sclerosis. Cortical demyelination may be the pathological substrate of progression, and an important pathologic correlate of irreversible disability, epilepsy and cognitive impairment. Cortical lesions of chronic progressive multiple sclerosis patients are characterized by a dominant effector cell population of microglia, by the absence of macrophagic and leukocytic inflammatory infiltrates, and may be driven in part by organized meningeal inflammatory infiltrates. Cortical demyelination is also present and common in early MS, is topographically associated with prominent meningeal inflammation and may even precede the appearance of classic white matter plaques in some MS patients. However, the pathology of early cortical lesions is different than that of chronic MS in the sense that early cortical lesions are highly inflammatory, suggesting that neurodegeneration in MS occurs on an inflammatory background and raising interesting questions regarding the role of cortical demyelination and meningeal inflammation in initiating and perpetuating the disease process in early MS. |
format | Online Article Text |
id | pubmed-3315403 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-33154032012-03-30 Meningeal and cortical grey matter pathology in multiple sclerosis Gh Popescu, Bogdan F Lucchinetti, Claudia F BMC Neurol Review Although historically considered a disease primarily affecting the white matter of the central nervous system, recent pathological and imaging studies have established that cortical demyelination is common in multiple sclerosis and more extensive than previously appreciated. Subpial, intracortical and leukocortical lesions are the three cortical lesion types described in the cerebral and cerebellar cortices of patients with multiple sclerosis. Cortical demyelination may be the pathological substrate of progression, and an important pathologic correlate of irreversible disability, epilepsy and cognitive impairment. Cortical lesions of chronic progressive multiple sclerosis patients are characterized by a dominant effector cell population of microglia, by the absence of macrophagic and leukocytic inflammatory infiltrates, and may be driven in part by organized meningeal inflammatory infiltrates. Cortical demyelination is also present and common in early MS, is topographically associated with prominent meningeal inflammation and may even precede the appearance of classic white matter plaques in some MS patients. However, the pathology of early cortical lesions is different than that of chronic MS in the sense that early cortical lesions are highly inflammatory, suggesting that neurodegeneration in MS occurs on an inflammatory background and raising interesting questions regarding the role of cortical demyelination and meningeal inflammation in initiating and perpetuating the disease process in early MS. BioMed Central 2012-03-07 /pmc/articles/PMC3315403/ /pubmed/22397318 http://dx.doi.org/10.1186/1471-2377-12-11 Text en Copyright ©2012 Gh Popescu and Lucchinetti; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Gh Popescu, Bogdan F Lucchinetti, Claudia F Meningeal and cortical grey matter pathology in multiple sclerosis |
title | Meningeal and cortical grey matter pathology in multiple sclerosis |
title_full | Meningeal and cortical grey matter pathology in multiple sclerosis |
title_fullStr | Meningeal and cortical grey matter pathology in multiple sclerosis |
title_full_unstemmed | Meningeal and cortical grey matter pathology in multiple sclerosis |
title_short | Meningeal and cortical grey matter pathology in multiple sclerosis |
title_sort | meningeal and cortical grey matter pathology in multiple sclerosis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315403/ https://www.ncbi.nlm.nih.gov/pubmed/22397318 http://dx.doi.org/10.1186/1471-2377-12-11 |
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