Cargando…

Sequence variants of interleukin 6 (IL-6) are significantly associated with a decreased risk of late-onset Alzheimer's disease

BACKGROUND: Interleukin 6 (IL-6) has been related to beta-amyloid aggregation and the appearance of hyperphosphorylated tau in Alzheimer's disease (AD) brain. However, previous studies relating IL-6 genetic polymorphisms to AD included few and unrepresentative single nucleotide polymorphisms (S...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Shih-Yuan, Chen, Ta-Fu, Lai, Liang-Chuan, Chen, Jen-Hau, Sun, Yu, Wen, Li-Li, Yip, Ping-Keung, Chu, Yi-Min, Chen, Yen-Ching
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315433/ https://www.ncbi.nlm.nih.gov/pubmed/22272811 http://dx.doi.org/10.1186/1742-2094-9-21

Ejemplares similares

Performance Metrics for Selecting Single Nucleotide Polymorphisms in Late-onset Alzheimer’s Disease
por: Chen, Yen-Ching, et al.
Publicado: (2016)

Sequence Variants of Toll Like Receptor 4 and Late-Onset Alzheimer's Disease
por: Chen, Yen-Ching, et al.
Publicado: (2012)

Genetic Polymorphisms of a Novel Vascular Susceptibility Gene, Ninjurin2 (NINJ2), Are Associated with a Decreased Risk of Alzheimer's Disease
por: Lin, Kun-Pei, et al.
Publicado: (2011)

Clinical significance of interleukin (IL)-6 in cancer metastasis to bone: potential of anti-IL-6 therapies
por: Tawara, Ken, et al.
Publicado: (2011)

Interleukin-6-knockdown of chimeric antigen receptor-modified T cells significantly reduces IL-6 release from monocytes
por: Kang, Liqing, et al.
Publicado: (2020)

Isorhamnetin Attenuated the Release of Interleukin-6 from β-Amyloid-Activated Microglia and Mitigated Interleukin-6-Mediated Neurotoxicity
por: Wei, Pei-Cih, et al.
Publicado: (2022)

Special issue on Interleukin-6 (IL-6)
por: Rincon, Mercedes
Publicado: (2012)

CHRNA7 Polymorphisms and Response to Cholinesterase Inhibitors in Alzheimer's Disease
por: Weng, Pei-Hsuan, et al.
Publicado: (2013)

CHRNA7 Polymorphisms and Dementia Risk: Interactions with Apolipoprotein ε4 and Cigarette Smoking
por: Weng, Pei-Hsuan, et al.
Publicado: (2016)

HBV replication is significantly reduced by IL-6
por: Kuo, Tzer-Min, et al.
Publicado: (2009)

The value of interleukin-6 (IL-6) within 6 hours after birth in the prompt diagnosis of early-onset neonatal sepsis
por: Liu, Chunmei, et al.
Publicado: (2020)

Interleukin (IL)-6 and IL-10 Are Up Regulated in Late Stage Trypanosoma brucei rhodesiense Sleeping Sickness
por: Kato, Charles D., et al.
Publicado: (2015)

Genetic polymorphisms of nerve growth factor receptor (NGFR) and the risk of Alzheimer's disease
por: Cheng, Hui-Chi, et al.
Publicado: (2012)

Interleukin-6 (IL-6) Receptor Antagonist Protects Against Rheumatoid Arthritis
por: Li, Songsong, et al.
Publicado: (2016)

The role of IL-6 in the radiation response of prostate cancer
por: Wu, Chun-Te, et al.
Publicado: (2013)

Role of interleukin 4 (IL4) and interleukin 6 (IL6) in the pathogenesis and prognosis of childhood primary immune thrombocytopenia
por: Zakaria, Marwa, et al.
Publicado: (2023)

Role of Interleukin-6 in Depressive Disorder
por: Ting, Emily Yi-Chih, et al.
Publicado: (2020)

Clinical significance of interleukin-6 and inducible nitric oxide synthase in ketamine-induced cystitis
por: Huang, Chi-Jung, et al.
Publicado: (2018)

SUN-118 Interleukin-6 (IL-6) Decreases Mitochondrial Biogenesis In 3T3-L1 Pre-adipocytes And Adipocytes
por: Nair, Saraswathy, et al.
Publicado: (2019)

Cathepsin S provokes interleukin-6 (IL-6) trans-signaling through cleavage of the IL-6 receptor in vitro
por: Flynn, Charlotte M., et al.
Publicado: (2020)

Role of interleukin-6 (IL-6) in predicting gestational diabetes mellitus
por: Amirian, Azam, et al.
Publicado: (2020)

Suppression of interleukin-6 increases enterovirus A71 lethality in mice
por: Wang, Li-Chiu, et al.
Publicado: (2017)

Association between air pollutants and dementia risk in the elderly
por: Wu, Yun-Chun, et al.
Publicado: (2015)

Significance of Interleukin-6 in Papillary Thyroid Carcinoma
por: Kobawala, Toral P., et al.
Publicado: (2016)

Variation and significance of secretory immunoglobulin A, interleukin 6 and dendritic cells in oral cancer
por: Zhang, Suxin, et al.
Publicado: (2017)

Significance of the TGF-β1/IL-6 axis in oral cancer
por: Chen, Miao-Fen, et al.
Publicado: (2012)

Interleukin‐6 signaling requires only few IL‐6 molecules: Relation to physiological concentrations of extracellular IL‐6
por: Hansen, Morten B.
Publicado: (2020)

Late-onset symptomatic hyperprolactinemia in 6-pyruvoyl-tetrahydropterin synthase deficiency
por: Hsu, Rai-Hseng, et al.
Publicado: (2023)

Enhanced IL-6/IL-6R Signaling Promotes Growth and Malignant Properties in EBV-Infected Premalignant and Cancerous Nasopharyngeal Epithelial Cells
por: Zhang, Guitao, et al.
Publicado: (2013)

The function of the soluble interleukin 6 (IL-6) receptor in vivo: sensitization of human soluble IL-6 receptor transgenic mice towards IL- 6 and prolongation of the plasma half-life of IL-6
Publicado: (1996)

Structural Mimicry of Receptor Interaction by Antagonistic Interleukin-6 (IL-6) Antibodies
por: Blanchetot, Christophe, et al.
Publicado: (2016)

Tocilizumab does not block interleukin-6 (IL-6) signaling in murine cells
por: Lokau, Juliane, et al.
Publicado: (2020)

Interleukin-6 receptor in the recent-onset rheumatoid arthritis
por: Montes-Cano, Marco Antonio, et al.
Publicado: (2011)

MiR-125a-5p Decreases the Sensitivity of Treg cells Toward IL-6-Mediated Conversion by Inhibiting IL-6R and STAT3 Expression
por: Li, Dan, et al.
Publicado: (2015)

The clinicopathological significance of NAB2‐STAT6 gene fusions in 52 cases of intrathoracic solitary fibrous tumors
por: Huang, Shih‐Chiang, et al.
Publicado: (2015)

Assessment of Interleukins IL-4, IL-6, IL-8, IL-10 in Acute Urticaria
por: Papadopoulos, Jordan, et al.
Publicado: (2014)

Serum Interleukin-6 Expression Level and Its Clinical Significance in Patients with Dermatomyositis
por: Yang, Min, et al.
Publicado: (2013)

Evaluation of the significance of interleukin-6 in the diagnosis of postoperative pneumonia: a prospective study
por: Chen, Wei, et al.
Publicado: (2022)

Clinicopathological significance of overexpression of interleukin-6 in colorectal cancer
por: Zeng, Jun, et al.
Publicado: (2017)

Accelerated Nerve Regeneration in Mice by upregulated expression of interleukin (IL) 6 and IL-6 receptor after trauma
Publicado: (1996)

Cannot write session to /tmp/vufind_sessions/sess_sdl5rmnrb8j2d7rgr70bf2h9ok