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Thermodynamic State Ensemble Models of cis-Regulation
A major goal in computational biology is to develop models that accurately predict a gene's expression from its surrounding regulatory DNA. Here we present one class of such models, thermodynamic state ensemble models. We describe the biochemical derivation of the thermodynamic framework in sim...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315449/ https://www.ncbi.nlm.nih.gov/pubmed/22479169 http://dx.doi.org/10.1371/journal.pcbi.1002407 |