Cargando…
Genome-Wide Association and Functional Follow-Up Reveals New Loci for Kidney Function
Chronic kidney disease (CKD) is an important public health problem with a genetic component. We performed genome-wide association studies in up to 130,600 European ancestry participants overall, and stratified for key CKD risk factors. We uncovered 6 new loci in association with estimated glomerular...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2012
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315455/ https://www.ncbi.nlm.nih.gov/pubmed/22479191 http://dx.doi.org/10.1371/journal.pgen.1002584 |
| _version_ | 1782228232899133440 |
|---|---|
| author | Pattaro, Cristian Köttgen, Anna Teumer, Alexander Garnaas, Maija Böger, Carsten A. Fuchsberger, Christian Olden, Matthias Chen, Ming-Huei Tin, Adrienne Taliun, Daniel Li, Man Gao, Xiaoyi Gorski, Mathias Yang, Qiong Hundertmark, Claudia Foster, Meredith C. O'Seaghdha, Conall M. Glazer, Nicole Isaacs, Aaron Liu, Ching-Ti Smith, Albert V. O'Connell, Jeffrey R. Struchalin, Maksim Tanaka, Toshiko Li, Guo Johnson, Andrew D. Gierman, Hinco J. Feitosa, Mary Hwang, Shih-Jen Atkinson, Elizabeth J. Lohman, Kurt Cornelis, Marilyn C. Johansson, Åsa Tönjes, Anke Dehghan, Abbas Chouraki, Vincent Holliday, Elizabeth G. Sorice, Rossella Kutalik, Zoltan Lehtimäki, Terho Esko, Tõnu Deshmukh, Harshal Ulivi, Sheila Chu, Audrey Y. Murgia, Federico Trompet, Stella Imboden, Medea Kollerits, Barbara Pistis, Giorgio Harris, Tamara B. Launer, Lenore J. Aspelund, Thor Eiriksdottir, Gudny Mitchell, Braxton D. Boerwinkle, Eric Schmidt, Helena Cavalieri, Margherita Rao, Madhumathi Hu, Frank B. Demirkan, Ayse Oostra, Ben A. de Andrade, Mariza Turner, Stephen T. Ding, Jingzhong Andrews, Jeanette S. Freedman, Barry I. Koenig, Wolfgang Illig, Thomas Döring, Angela Wichmann, H.-Erich Kolcic, Ivana Zemunik, Tatijana Boban, Mladen Minelli, Cosetta Wheeler, Heather E. Igl, Wilmar Zaboli, Ghazal Wild, Sarah H. Wright, Alan F. Campbell, Harry Ellinghaus, David Nöthlings, Ute Jacobs, Gunnar Biffar, Reiner Endlich, Karlhans Ernst, Florian Homuth, Georg Kroemer, Heyo K. Nauck, Matthias Stracke, Sylvia Völker, Uwe Völzke, Henry Kovacs, Peter Stumvoll, Michael Mägi, Reedik Hofman, Albert Uitterlinden, Andre G. Rivadeneira, Fernando Aulchenko, Yurii S. Polasek, Ozren Hastie, Nick Vitart, Veronique Helmer, Catherine Wang, Jie Jin Ruggiero, Daniela Bergmann, Sven Kähönen, Mika Viikari, Jorma Nikopensius, Tiit Province, Michael Ketkar, Shamika Colhoun, Helen Doney, Alex Robino, Antonietta Giulianini, Franco Krämer, Bernhard K. Portas, Laura Ford, Ian Buckley, Brendan M. Adam, Martin Thun, Gian-Andri Paulweber, Bernhard Haun, Margot Sala, Cinzia Metzger, Marie Mitchell, Paul Ciullo, Marina Kim, Stuart K. Vollenweider, Peter Raitakari, Olli Metspalu, Andres Palmer, Colin Gasparini, Paolo Pirastu, Mario Jukema, J. Wouter Probst-Hensch, Nicole M. Kronenberg, Florian Toniolo, Daniela Gudnason, Vilmundur Shuldiner, Alan R. Coresh, Josef Schmidt, Reinhold Ferrucci, Luigi Siscovick, David S. van Duijn, Cornelia M. Borecki, Ingrid Kardia, Sharon L. R. Liu, Yongmei Curhan, Gary C. Rudan, Igor Gyllensten, Ulf Wilson, James F. Franke, Andre Pramstaller, Peter P. Rettig, Rainer Prokopenko, Inga Witteman, Jacqueline C. M. Hayward, Caroline Ridker, Paul Parsa, Afshin Bochud, Murielle Heid, Iris M. Goessling, Wolfram Chasman, Daniel I. Kao, W. H. Linda Fox, Caroline S. |
| author_facet | Pattaro, Cristian Köttgen, Anna Teumer, Alexander Garnaas, Maija Böger, Carsten A. Fuchsberger, Christian Olden, Matthias Chen, Ming-Huei Tin, Adrienne Taliun, Daniel Li, Man Gao, Xiaoyi Gorski, Mathias Yang, Qiong Hundertmark, Claudia Foster, Meredith C. O'Seaghdha, Conall M. Glazer, Nicole Isaacs, Aaron Liu, Ching-Ti Smith, Albert V. O'Connell, Jeffrey R. Struchalin, Maksim Tanaka, Toshiko Li, Guo Johnson, Andrew D. Gierman, Hinco J. Feitosa, Mary Hwang, Shih-Jen Atkinson, Elizabeth J. Lohman, Kurt Cornelis, Marilyn C. Johansson, Åsa Tönjes, Anke Dehghan, Abbas Chouraki, Vincent Holliday, Elizabeth G. Sorice, Rossella Kutalik, Zoltan Lehtimäki, Terho Esko, Tõnu Deshmukh, Harshal Ulivi, Sheila Chu, Audrey Y. Murgia, Federico Trompet, Stella Imboden, Medea Kollerits, Barbara Pistis, Giorgio Harris, Tamara B. Launer, Lenore J. Aspelund, Thor Eiriksdottir, Gudny Mitchell, Braxton D. Boerwinkle, Eric Schmidt, Helena Cavalieri, Margherita Rao, Madhumathi Hu, Frank B. Demirkan, Ayse Oostra, Ben A. de Andrade, Mariza Turner, Stephen T. Ding, Jingzhong Andrews, Jeanette S. Freedman, Barry I. Koenig, Wolfgang Illig, Thomas Döring, Angela Wichmann, H.-Erich Kolcic, Ivana Zemunik, Tatijana Boban, Mladen Minelli, Cosetta Wheeler, Heather E. Igl, Wilmar Zaboli, Ghazal Wild, Sarah H. Wright, Alan F. Campbell, Harry Ellinghaus, David Nöthlings, Ute Jacobs, Gunnar Biffar, Reiner Endlich, Karlhans Ernst, Florian Homuth, Georg Kroemer, Heyo K. Nauck, Matthias Stracke, Sylvia Völker, Uwe Völzke, Henry Kovacs, Peter Stumvoll, Michael Mägi, Reedik Hofman, Albert Uitterlinden, Andre G. Rivadeneira, Fernando Aulchenko, Yurii S. Polasek, Ozren Hastie, Nick Vitart, Veronique Helmer, Catherine Wang, Jie Jin Ruggiero, Daniela Bergmann, Sven Kähönen, Mika Viikari, Jorma Nikopensius, Tiit Province, Michael Ketkar, Shamika Colhoun, Helen Doney, Alex Robino, Antonietta Giulianini, Franco Krämer, Bernhard K. Portas, Laura Ford, Ian Buckley, Brendan M. Adam, Martin Thun, Gian-Andri Paulweber, Bernhard Haun, Margot Sala, Cinzia Metzger, Marie Mitchell, Paul Ciullo, Marina Kim, Stuart K. Vollenweider, Peter Raitakari, Olli Metspalu, Andres Palmer, Colin Gasparini, Paolo Pirastu, Mario Jukema, J. Wouter Probst-Hensch, Nicole M. Kronenberg, Florian Toniolo, Daniela Gudnason, Vilmundur Shuldiner, Alan R. Coresh, Josef Schmidt, Reinhold Ferrucci, Luigi Siscovick, David S. van Duijn, Cornelia M. Borecki, Ingrid Kardia, Sharon L. R. Liu, Yongmei Curhan, Gary C. Rudan, Igor Gyllensten, Ulf Wilson, James F. Franke, Andre Pramstaller, Peter P. Rettig, Rainer Prokopenko, Inga Witteman, Jacqueline C. M. Hayward, Caroline Ridker, Paul Parsa, Afshin Bochud, Murielle Heid, Iris M. Goessling, Wolfram Chasman, Daniel I. Kao, W. H. Linda Fox, Caroline S. |
| author_sort | Pattaro, Cristian |
| collection | PubMed |
| description | Chronic kidney disease (CKD) is an important public health problem with a genetic component. We performed genome-wide association studies in up to 130,600 European ancestry participants overall, and stratified for key CKD risk factors. We uncovered 6 new loci in association with estimated glomerular filtration rate (eGFR), the primary clinical measure of CKD, in or near MPPED2, DDX1, SLC47A1, CDK12, CASP9, and INO80. Morpholino knockdown of mpped2 and casp9 in zebrafish embryos revealed podocyte and tubular abnormalities with altered dextran clearance, suggesting a role for these genes in renal function. By providing new insights into genes that regulate renal function, these results could further our understanding of the pathogenesis of CKD. |
| format | Online Article Text |
| id | pubmed-3315455 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2012 |
| publisher | Public Library of Science |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-33154552012-04-04 Genome-Wide Association and Functional Follow-Up Reveals New Loci for Kidney Function Pattaro, Cristian Köttgen, Anna Teumer, Alexander Garnaas, Maija Böger, Carsten A. Fuchsberger, Christian Olden, Matthias Chen, Ming-Huei Tin, Adrienne Taliun, Daniel Li, Man Gao, Xiaoyi Gorski, Mathias Yang, Qiong Hundertmark, Claudia Foster, Meredith C. O'Seaghdha, Conall M. Glazer, Nicole Isaacs, Aaron Liu, Ching-Ti Smith, Albert V. O'Connell, Jeffrey R. Struchalin, Maksim Tanaka, Toshiko Li, Guo Johnson, Andrew D. Gierman, Hinco J. Feitosa, Mary Hwang, Shih-Jen Atkinson, Elizabeth J. Lohman, Kurt Cornelis, Marilyn C. Johansson, Åsa Tönjes, Anke Dehghan, Abbas Chouraki, Vincent Holliday, Elizabeth G. Sorice, Rossella Kutalik, Zoltan Lehtimäki, Terho Esko, Tõnu Deshmukh, Harshal Ulivi, Sheila Chu, Audrey Y. Murgia, Federico Trompet, Stella Imboden, Medea Kollerits, Barbara Pistis, Giorgio Harris, Tamara B. Launer, Lenore J. Aspelund, Thor Eiriksdottir, Gudny Mitchell, Braxton D. Boerwinkle, Eric Schmidt, Helena Cavalieri, Margherita Rao, Madhumathi Hu, Frank B. Demirkan, Ayse Oostra, Ben A. de Andrade, Mariza Turner, Stephen T. Ding, Jingzhong Andrews, Jeanette S. Freedman, Barry I. Koenig, Wolfgang Illig, Thomas Döring, Angela Wichmann, H.-Erich Kolcic, Ivana Zemunik, Tatijana Boban, Mladen Minelli, Cosetta Wheeler, Heather E. Igl, Wilmar Zaboli, Ghazal Wild, Sarah H. Wright, Alan F. Campbell, Harry Ellinghaus, David Nöthlings, Ute Jacobs, Gunnar Biffar, Reiner Endlich, Karlhans Ernst, Florian Homuth, Georg Kroemer, Heyo K. Nauck, Matthias Stracke, Sylvia Völker, Uwe Völzke, Henry Kovacs, Peter Stumvoll, Michael Mägi, Reedik Hofman, Albert Uitterlinden, Andre G. Rivadeneira, Fernando Aulchenko, Yurii S. Polasek, Ozren Hastie, Nick Vitart, Veronique Helmer, Catherine Wang, Jie Jin Ruggiero, Daniela Bergmann, Sven Kähönen, Mika Viikari, Jorma Nikopensius, Tiit Province, Michael Ketkar, Shamika Colhoun, Helen Doney, Alex Robino, Antonietta Giulianini, Franco Krämer, Bernhard K. Portas, Laura Ford, Ian Buckley, Brendan M. Adam, Martin Thun, Gian-Andri Paulweber, Bernhard Haun, Margot Sala, Cinzia Metzger, Marie Mitchell, Paul Ciullo, Marina Kim, Stuart K. Vollenweider, Peter Raitakari, Olli Metspalu, Andres Palmer, Colin Gasparini, Paolo Pirastu, Mario Jukema, J. Wouter Probst-Hensch, Nicole M. Kronenberg, Florian Toniolo, Daniela Gudnason, Vilmundur Shuldiner, Alan R. Coresh, Josef Schmidt, Reinhold Ferrucci, Luigi Siscovick, David S. van Duijn, Cornelia M. Borecki, Ingrid Kardia, Sharon L. R. Liu, Yongmei Curhan, Gary C. Rudan, Igor Gyllensten, Ulf Wilson, James F. Franke, Andre Pramstaller, Peter P. Rettig, Rainer Prokopenko, Inga Witteman, Jacqueline C. M. Hayward, Caroline Ridker, Paul Parsa, Afshin Bochud, Murielle Heid, Iris M. Goessling, Wolfram Chasman, Daniel I. Kao, W. H. Linda Fox, Caroline S. PLoS Genet Research Article Chronic kidney disease (CKD) is an important public health problem with a genetic component. We performed genome-wide association studies in up to 130,600 European ancestry participants overall, and stratified for key CKD risk factors. We uncovered 6 new loci in association with estimated glomerular filtration rate (eGFR), the primary clinical measure of CKD, in or near MPPED2, DDX1, SLC47A1, CDK12, CASP9, and INO80. Morpholino knockdown of mpped2 and casp9 in zebrafish embryos revealed podocyte and tubular abnormalities with altered dextran clearance, suggesting a role for these genes in renal function. By providing new insights into genes that regulate renal function, these results could further our understanding of the pathogenesis of CKD. Public Library of Science 2012-03-29 /pmc/articles/PMC3315455/ /pubmed/22479191 http://dx.doi.org/10.1371/journal.pgen.1002584 Text en Pattaro et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
| spellingShingle | Research Article Pattaro, Cristian Köttgen, Anna Teumer, Alexander Garnaas, Maija Böger, Carsten A. Fuchsberger, Christian Olden, Matthias Chen, Ming-Huei Tin, Adrienne Taliun, Daniel Li, Man Gao, Xiaoyi Gorski, Mathias Yang, Qiong Hundertmark, Claudia Foster, Meredith C. O'Seaghdha, Conall M. Glazer, Nicole Isaacs, Aaron Liu, Ching-Ti Smith, Albert V. O'Connell, Jeffrey R. Struchalin, Maksim Tanaka, Toshiko Li, Guo Johnson, Andrew D. Gierman, Hinco J. Feitosa, Mary Hwang, Shih-Jen Atkinson, Elizabeth J. Lohman, Kurt Cornelis, Marilyn C. Johansson, Åsa Tönjes, Anke Dehghan, Abbas Chouraki, Vincent Holliday, Elizabeth G. Sorice, Rossella Kutalik, Zoltan Lehtimäki, Terho Esko, Tõnu Deshmukh, Harshal Ulivi, Sheila Chu, Audrey Y. Murgia, Federico Trompet, Stella Imboden, Medea Kollerits, Barbara Pistis, Giorgio Harris, Tamara B. Launer, Lenore J. Aspelund, Thor Eiriksdottir, Gudny Mitchell, Braxton D. Boerwinkle, Eric Schmidt, Helena Cavalieri, Margherita Rao, Madhumathi Hu, Frank B. Demirkan, Ayse Oostra, Ben A. de Andrade, Mariza Turner, Stephen T. Ding, Jingzhong Andrews, Jeanette S. Freedman, Barry I. Koenig, Wolfgang Illig, Thomas Döring, Angela Wichmann, H.-Erich Kolcic, Ivana Zemunik, Tatijana Boban, Mladen Minelli, Cosetta Wheeler, Heather E. Igl, Wilmar Zaboli, Ghazal Wild, Sarah H. Wright, Alan F. Campbell, Harry Ellinghaus, David Nöthlings, Ute Jacobs, Gunnar Biffar, Reiner Endlich, Karlhans Ernst, Florian Homuth, Georg Kroemer, Heyo K. Nauck, Matthias Stracke, Sylvia Völker, Uwe Völzke, Henry Kovacs, Peter Stumvoll, Michael Mägi, Reedik Hofman, Albert Uitterlinden, Andre G. Rivadeneira, Fernando Aulchenko, Yurii S. Polasek, Ozren Hastie, Nick Vitart, Veronique Helmer, Catherine Wang, Jie Jin Ruggiero, Daniela Bergmann, Sven Kähönen, Mika Viikari, Jorma Nikopensius, Tiit Province, Michael Ketkar, Shamika Colhoun, Helen Doney, Alex Robino, Antonietta Giulianini, Franco Krämer, Bernhard K. Portas, Laura Ford, Ian Buckley, Brendan M. Adam, Martin Thun, Gian-Andri Paulweber, Bernhard Haun, Margot Sala, Cinzia Metzger, Marie Mitchell, Paul Ciullo, Marina Kim, Stuart K. Vollenweider, Peter Raitakari, Olli Metspalu, Andres Palmer, Colin Gasparini, Paolo Pirastu, Mario Jukema, J. Wouter Probst-Hensch, Nicole M. Kronenberg, Florian Toniolo, Daniela Gudnason, Vilmundur Shuldiner, Alan R. Coresh, Josef Schmidt, Reinhold Ferrucci, Luigi Siscovick, David S. van Duijn, Cornelia M. Borecki, Ingrid Kardia, Sharon L. R. Liu, Yongmei Curhan, Gary C. Rudan, Igor Gyllensten, Ulf Wilson, James F. Franke, Andre Pramstaller, Peter P. Rettig, Rainer Prokopenko, Inga Witteman, Jacqueline C. M. Hayward, Caroline Ridker, Paul Parsa, Afshin Bochud, Murielle Heid, Iris M. Goessling, Wolfram Chasman, Daniel I. Kao, W. H. Linda Fox, Caroline S. Genome-Wide Association and Functional Follow-Up Reveals New Loci for Kidney Function |
| title | Genome-Wide Association and Functional Follow-Up Reveals New Loci for Kidney Function |
| title_full | Genome-Wide Association and Functional Follow-Up Reveals New Loci for Kidney Function |
| title_fullStr | Genome-Wide Association and Functional Follow-Up Reveals New Loci for Kidney Function |
| title_full_unstemmed | Genome-Wide Association and Functional Follow-Up Reveals New Loci for Kidney Function |
| title_short | Genome-Wide Association and Functional Follow-Up Reveals New Loci for Kidney Function |
| title_sort | genome-wide association and functional follow-up reveals new loci for kidney function |
| topic | Research Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315455/ https://www.ncbi.nlm.nih.gov/pubmed/22479191 http://dx.doi.org/10.1371/journal.pgen.1002584 |
| work_keys_str_mv | AT pattarocristian genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT kottgenanna genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT teumeralexander genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT garnaasmaija genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT bogercarstena genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT fuchsbergerchristian genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT oldenmatthias genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT chenminghuei genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT tinadrienne genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT taliundaniel genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT liman genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT gaoxiaoyi genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT gorskimathias genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT yangqiong genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT hundertmarkclaudia genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT fostermeredithc genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT oseaghdhaconallm genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT glazernicole genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT isaacsaaron genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT liuchingti genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT smithalbertv genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT oconnelljeffreyr genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT struchalinmaksim genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT tanakatoshiko genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT liguo genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT johnsonandrewd genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT giermanhincoj genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT feitosamary genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT hwangshihjen genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT atkinsonelizabethj genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT lohmankurt genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT cornelismarilync genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT johanssonasa genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT tonjesanke genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT dehghanabbas genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT chourakivincent genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT hollidayelizabethg genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT soricerossella genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT kutalikzoltan genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT lehtimakiterho genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT eskotonu genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT deshmukhharshal genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT ulivisheila genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT chuaudreyy genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT murgiafederico genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT trompetstella genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT imbodenmedea genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT kolleritsbarbara genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT pistisgiorgio genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT harristamarab genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT launerlenorej genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT aspelundthor genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT eiriksdottirgudny genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT mitchellbraxtond genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT boerwinkleeric genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT schmidthelena genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT cavalierimargherita genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT raomadhumathi genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT hufrankb genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT demirkanayse genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT oostrabena genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT deandrademariza genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT turnerstephent genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT dingjingzhong genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT andrewsjeanettes genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT freedmanbarryi genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT koenigwolfgang genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT illigthomas genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT doringangela genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT wichmannherich genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT kolcicivana genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT zemuniktatijana genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT bobanmladen genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT minellicosetta genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT wheelerheathere genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT iglwilmar genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT zabolighazal genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT wildsarahh genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT wrightalanf genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT campbellharry genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT ellinghausdavid genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT nothlingsute genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT jacobsgunnar genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT biffarreiner genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT endlichkarlhans genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT ernstflorian genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT homuthgeorg genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT kroemerheyok genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT nauckmatthias genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT strackesylvia genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT volkeruwe genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT volzkehenry genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT kovacspeter genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT stumvollmichael genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT magireedik genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT hofmanalbert genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT uitterlindenandreg genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT rivadeneirafernando genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT aulchenkoyuriis genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT polasekozren genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT hastienick genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT vitartveronique genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT helmercatherine genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT wangjiejin genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT ruggierodaniela genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT bergmannsven genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT kahonenmika genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT viikarijorma genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT nikopensiustiit genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT provincemichael genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT ketkarshamika genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT colhounhelen genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT doneyalex genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT robinoantonietta genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT giulianinifranco genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT kramerbernhardk genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT portaslaura genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT fordian genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT buckleybrendanm genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT adammartin genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT thungianandri genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT paulweberbernhard genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT haunmargot genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT salacinzia genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT metzgermarie genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT mitchellpaul genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT ciullomarina genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT kimstuartk genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT vollenweiderpeter genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT raitakariolli genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT metspaluandres genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT palmercolin genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT gasparinipaolo genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT pirastumario genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT jukemajwouter genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT probsthenschnicolem genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT kronenbergflorian genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT toniolodaniela genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT gudnasonvilmundur genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT shuldineralanr genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT coreshjosef genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT schmidtreinhold genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT ferrucciluigi genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT siscovickdavids genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT vanduijncorneliam genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT boreckiingrid genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT kardiasharonlr genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT liuyongmei genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT curhangaryc genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT rudanigor genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT gyllenstenulf genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT wilsonjamesf genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT frankeandre genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT pramstallerpeterp genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT rettigrainer genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT prokopenkoinga genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT wittemanjacquelinecm genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT haywardcaroline genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT ridkerpaul genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT parsaafshin genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT bochudmurielle genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT heidirism genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT goesslingwolfram genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT chasmandanieli genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT kaowhlinda genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction AT foxcarolines genomewideassociationandfunctionalfollowuprevealsnewlociforkidneyfunction |