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Statistical Analysis of Readthrough Levels for Nonsense Mutations in Mammalian Cells Reveals a Major Determinant of Response to Gentamicin

The efficiency of translation termination depends on the nature of the stop codon and the surrounding nucleotides. Some molecules, such as aminoglycoside antibiotics (gentamicin), decrease termination efficiency and are currently being evaluated for diseases caused by premature termination codons. H...

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Detalles Bibliográficos
Autores principales:	Floquet, Célia, Hatin, Isabelle, Rousset, Jean-Pierre, Bidou, Laure
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315467/ https://www.ncbi.nlm.nih.gov/pubmed/22479203 http://dx.doi.org/10.1371/journal.pgen.1002608

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