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Pharmacokinetic Modeling of an Induction Regimen for In Vivo Combined Testing of Novel Drugs against Pediatric Acute Lymphoblastic Leukemia Xenografts

Current regimens for induction therapy of pediatric acute lymphoblastic leukemia (ALL), or for re-induction post relapse, use a combination of vincristine (VCR), a glucocorticoid, and l-asparaginase (ASP) with or without an anthracycline. With cure rates now approximately 80%, robust pre-clinical mo...

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Detalles Bibliográficos
Autores principales:	Szymanska, Barbara, Wilczynska-Kalak, Urszula, Kang, Min H., Liem, Natalia L. M., Carol, Hernan, Boehm, Ingrid, Groepper, Daniel, Reynolds, C. Patrick, Stewart, Clinton F., Lock, Richard B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315513/ https://www.ncbi.nlm.nih.gov/pubmed/22479469 http://dx.doi.org/10.1371/journal.pone.0033894

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