Functional Validation of Hydrophobic Adaptation to Physiological Temperature in the Small Heat Shock Protein αA-crystallin

Small heat shock proteins (sHsps) maintain cellular homeostasis by preventing stress and disease-induced protein aggregation. While it is known that hydrophobicity impacts the ability of sHsps to bind aggregation-prone denaturing proteins, the complex quaternary structure of globular sHsps has made...

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Detalles Bibliográficos
Autores principales: Posner, Mason, Kiss, Andor J., Skiba, Jackie, Drossman, Amy, Dolinska, Monika B., Hejtmancik, J. Fielding, Sergeev, Yuri V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315530/
https://www.ncbi.nlm.nih.gov/pubmed/22479631
http://dx.doi.org/10.1371/journal.pone.0034438

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315530/
https://www.ncbi.nlm.nih.gov/pubmed/22479631
http://dx.doi.org/10.1371/journal.pone.0034438

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