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Persistent Cell-Autonomous Circadian Oscillations in Fibroblasts Revealed by Six-Week Single-Cell Imaging of PER2::LUC Bioluminescence

Biological oscillators naturally exhibit stochastic fluctuations in period and amplitude due to the random nature of molecular reactions. Accurately measuring the precision of noisy oscillators and the heterogeneity in period and strength of rhythmicity across a population of cells requires single-c...

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Detalles Bibliográficos
Autores principales: Leise, Tanya L., Wang, Connie W., Gitis, Paula J., Welsh, David K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315561/
https://www.ncbi.nlm.nih.gov/pubmed/22479387
http://dx.doi.org/10.1371/journal.pone.0033334