Loss of PTEN Is Not Associated with Poor Survival in Newly Diagnosed Glioblastoma Patients of the Temozolomide Era

INTRODUCTION: Pre-temozolomide studies demonstrated that loss of the tumor suppressor gene PTEN held independent prognostic significance in GBM patients. We investigated whether loss of PTEN predicted shorter survival in the temozolomide era. The role of PTEN in the PI3K/Akt pathway is also reviewed...

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Detalles Bibliográficos
Autores principales: Carico, Christine, Nuño, Miriam, Mukherjee, Debraj, Elramsisy, Adam, Dantis, Jocelynn, Hu, Jethro, Rudnick, Jeremy, Yu, John S., Black, Keith L., Bannykh, Serguei I., Patil, Chirag G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315579/
https://www.ncbi.nlm.nih.gov/pubmed/22479427
http://dx.doi.org/10.1371/journal.pone.0033684

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315579/
https://www.ncbi.nlm.nih.gov/pubmed/22479427
http://dx.doi.org/10.1371/journal.pone.0033684

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