Cargando…

Efficacy of dexamethasone added to ramosetron for preventing postoperative nausea and vomiting in highly susceptible patients following spine surgery

BACKGROUND: Opioid-based patient controlled analgesia (PCA) provides adequate pain control following spinal surgeries at the expense of increased risk of postoperative nausea and vomiting (PONV). We evaluated the efficacy of dexamethasone added to ramosetron, which is a newly developed five-hydroxyt...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, So-Young, Jun, Na-Hyung, Choi, Yong-Seon, Kim, Jong Chan, Shim, Jae-Kwang, Ha, Sang-Hee, Kwak, Young Lan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Anesthesiologists 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315657/
https://www.ncbi.nlm.nih.gov/pubmed/22474554
http://dx.doi.org/10.4097/kjae.2012.62.3.260
_version_ 1782228270416134144
author Yang, So-Young
Jun, Na-Hyung
Choi, Yong-Seon
Kim, Jong Chan
Shim, Jae-Kwang
Ha, Sang-Hee
Kwak, Young Lan
author_facet Yang, So-Young
Jun, Na-Hyung
Choi, Yong-Seon
Kim, Jong Chan
Shim, Jae-Kwang
Ha, Sang-Hee
Kwak, Young Lan
author_sort Yang, So-Young
collection PubMed
description BACKGROUND: Opioid-based patient controlled analgesia (PCA) provides adequate pain control following spinal surgeries at the expense of increased risk of postoperative nausea and vomiting (PONV). We evaluated the efficacy of dexamethasone added to ramosetron, which is a newly developed five-hydroxytryptamine receptor 3 antagonist with a higher receptor affinity and longer action duration compared to its congeners, on preventing PONV in highly susceptible patients receiving opioid-based IV PCA after spinal surgery. METHODS: One hundred nonsmoking female patients undergoing spinal surgery were randomly allocated to either a ramosetron group (group R) or a ramosetron plus dexamethasone group (group RD)., Normal saline (1 ml) or 5 mg of dexamethasone was injected before anesthetic induction, while at the end of the surgery, ramosetron (0.3 mg) was administered to all patients and fentanyl-based IV PCA was continued for 48 hrs. The incidence and severity of PONV, pain score and the amount of rescue antiemetics were assessed for 48 hours after surgery. RESULTS: The number of patients with moderate to severe nausea (20 vs. 10, P = 0.029), and overall incidence of vomiting (13 vs. 5, P = 0.037) were significantly lower in the group RD than in the group R, respectively. Rescue antiemetic was used less in the RD group without significance. CONCLUSIONS: Combination of ramosetron and dexamethasone significantly reduced the incidence of moderate to severe nausea and vomiting compared to ramosetron alone in highly susceptible patients receiving opioid-based IV PCA after surgery.
format Online
Article
Text
id pubmed-3315657
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher The Korean Society of Anesthesiologists
record_format MEDLINE/PubMed
spelling pubmed-33156572012-04-03 Efficacy of dexamethasone added to ramosetron for preventing postoperative nausea and vomiting in highly susceptible patients following spine surgery Yang, So-Young Jun, Na-Hyung Choi, Yong-Seon Kim, Jong Chan Shim, Jae-Kwang Ha, Sang-Hee Kwak, Young Lan Korean J Anesthesiol Clinical Research Article BACKGROUND: Opioid-based patient controlled analgesia (PCA) provides adequate pain control following spinal surgeries at the expense of increased risk of postoperative nausea and vomiting (PONV). We evaluated the efficacy of dexamethasone added to ramosetron, which is a newly developed five-hydroxytryptamine receptor 3 antagonist with a higher receptor affinity and longer action duration compared to its congeners, on preventing PONV in highly susceptible patients receiving opioid-based IV PCA after spinal surgery. METHODS: One hundred nonsmoking female patients undergoing spinal surgery were randomly allocated to either a ramosetron group (group R) or a ramosetron plus dexamethasone group (group RD)., Normal saline (1 ml) or 5 mg of dexamethasone was injected before anesthetic induction, while at the end of the surgery, ramosetron (0.3 mg) was administered to all patients and fentanyl-based IV PCA was continued for 48 hrs. The incidence and severity of PONV, pain score and the amount of rescue antiemetics were assessed for 48 hours after surgery. RESULTS: The number of patients with moderate to severe nausea (20 vs. 10, P = 0.029), and overall incidence of vomiting (13 vs. 5, P = 0.037) were significantly lower in the group RD than in the group R, respectively. Rescue antiemetic was used less in the RD group without significance. CONCLUSIONS: Combination of ramosetron and dexamethasone significantly reduced the incidence of moderate to severe nausea and vomiting compared to ramosetron alone in highly susceptible patients receiving opioid-based IV PCA after surgery. The Korean Society of Anesthesiologists 2012-03 2012-03-21 /pmc/articles/PMC3315657/ /pubmed/22474554 http://dx.doi.org/10.4097/kjae.2012.62.3.260 Text en Copyright © the Korean Society of Anesthesiologists, 2012 http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Research Article
Yang, So-Young
Jun, Na-Hyung
Choi, Yong-Seon
Kim, Jong Chan
Shim, Jae-Kwang
Ha, Sang-Hee
Kwak, Young Lan
Efficacy of dexamethasone added to ramosetron for preventing postoperative nausea and vomiting in highly susceptible patients following spine surgery
title Efficacy of dexamethasone added to ramosetron for preventing postoperative nausea and vomiting in highly susceptible patients following spine surgery
title_full Efficacy of dexamethasone added to ramosetron for preventing postoperative nausea and vomiting in highly susceptible patients following spine surgery
title_fullStr Efficacy of dexamethasone added to ramosetron for preventing postoperative nausea and vomiting in highly susceptible patients following spine surgery
title_full_unstemmed Efficacy of dexamethasone added to ramosetron for preventing postoperative nausea and vomiting in highly susceptible patients following spine surgery
title_short Efficacy of dexamethasone added to ramosetron for preventing postoperative nausea and vomiting in highly susceptible patients following spine surgery
title_sort efficacy of dexamethasone added to ramosetron for preventing postoperative nausea and vomiting in highly susceptible patients following spine surgery
topic Clinical Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315657/
https://www.ncbi.nlm.nih.gov/pubmed/22474554
http://dx.doi.org/10.4097/kjae.2012.62.3.260
work_keys_str_mv AT yangsoyoung efficacyofdexamethasoneaddedtoramosetronforpreventingpostoperativenauseaandvomitinginhighlysusceptiblepatientsfollowingspinesurgery
AT junnahyung efficacyofdexamethasoneaddedtoramosetronforpreventingpostoperativenauseaandvomitinginhighlysusceptiblepatientsfollowingspinesurgery
AT choiyongseon efficacyofdexamethasoneaddedtoramosetronforpreventingpostoperativenauseaandvomitinginhighlysusceptiblepatientsfollowingspinesurgery
AT kimjongchan efficacyofdexamethasoneaddedtoramosetronforpreventingpostoperativenauseaandvomitinginhighlysusceptiblepatientsfollowingspinesurgery
AT shimjaekwang efficacyofdexamethasoneaddedtoramosetronforpreventingpostoperativenauseaandvomitinginhighlysusceptiblepatientsfollowingspinesurgery
AT hasanghee efficacyofdexamethasoneaddedtoramosetronforpreventingpostoperativenauseaandvomitinginhighlysusceptiblepatientsfollowingspinesurgery
AT kwakyounglan efficacyofdexamethasoneaddedtoramosetronforpreventingpostoperativenauseaandvomitinginhighlysusceptiblepatientsfollowingspinesurgery