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Osseointegration and biocompatibility of different metal implants - a comparative experimental investigation in sheep

BACKGROUND: In the present study, 4 different metallic implant materials, either partly coated or polished, were tested for their osseointegration and biocompatibility in a pelvic implantation model in sheep. METHODS: Materials to be evaluated were: Cobalt-Chrome (CC), Cobalt-Chrome/Titanium coating...

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Autores principales: Plecko, Michael, Sievert, Christine, Andermatt, Daniel, Frigg, Robert, Kronen, Peter, Klein, Karina, Stübinger, Stefan, Nuss, Katja, Bürki, Alexander, Ferguson, Stephen, Stoeckle, Ulrich, von Rechenberg, Brigitte
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315746/
https://www.ncbi.nlm.nih.gov/pubmed/22400715
http://dx.doi.org/10.1186/1471-2474-13-32
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author Plecko, Michael
Sievert, Christine
Andermatt, Daniel
Frigg, Robert
Kronen, Peter
Klein, Karina
Stübinger, Stefan
Nuss, Katja
Bürki, Alexander
Ferguson, Stephen
Stoeckle, Ulrich
von Rechenberg, Brigitte
author_facet Plecko, Michael
Sievert, Christine
Andermatt, Daniel
Frigg, Robert
Kronen, Peter
Klein, Karina
Stübinger, Stefan
Nuss, Katja
Bürki, Alexander
Ferguson, Stephen
Stoeckle, Ulrich
von Rechenberg, Brigitte
author_sort Plecko, Michael
collection PubMed
description BACKGROUND: In the present study, 4 different metallic implant materials, either partly coated or polished, were tested for their osseointegration and biocompatibility in a pelvic implantation model in sheep. METHODS: Materials to be evaluated were: Cobalt-Chrome (CC), Cobalt-Chrome/Titanium coating (CCTC), Cobalt-Chrome/Zirconium/Titanium coating (CCZTC), Pure Titanium Standard (PTST), Steel, TAN Standard (TANST) and TAN new finish (TANNEW). Surgery was performed on 7 sheep, with 18 implants per sheep, for a total of 63 implants. After 8 weeks, the specimens were harvested and evaluated macroscopically, radiologically, biomechanically (removal torque), histomorphometrically and histologically. RESULTS: Cobalt-Chrome screws showed significantly (p = 0.031) lower removal torque values than pure titanium screws and also a tendency towards lower values compared to the other materials, except for steel. Steel screws showed no significant differences, in comparison to cobalt-chrome and TANST, however also a trend towards lower torque values than the remaining materials. The results of the fluorescence sections agreed with those of the biomechanical test. Histomorphometrically, there were no significant differences of bone area between the groups. The BIC (bone-to-implant-contact), used for the assessment of the osseointegration, was significantly lower for cobalt-chrome, compared to steel (p = 0.001). Steel again showed a lower ratio (p = 0.0001) compared to the other materials. CONCLUSION: This study demonstrated that cobalt-chrome and steel show less osseointegration than the other metals and metal-alloys. However, osseointegration of cobalt-chrome was improved by zirconium and/or titanium based coatings (CCTC, TANST, TAN, TANNEW) being similar as pure titanium in their osseointegrative behavior.
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spelling pubmed-33157462012-03-31 Osseointegration and biocompatibility of different metal implants - a comparative experimental investigation in sheep Plecko, Michael Sievert, Christine Andermatt, Daniel Frigg, Robert Kronen, Peter Klein, Karina Stübinger, Stefan Nuss, Katja Bürki, Alexander Ferguson, Stephen Stoeckle, Ulrich von Rechenberg, Brigitte BMC Musculoskelet Disord Research Article BACKGROUND: In the present study, 4 different metallic implant materials, either partly coated or polished, were tested for their osseointegration and biocompatibility in a pelvic implantation model in sheep. METHODS: Materials to be evaluated were: Cobalt-Chrome (CC), Cobalt-Chrome/Titanium coating (CCTC), Cobalt-Chrome/Zirconium/Titanium coating (CCZTC), Pure Titanium Standard (PTST), Steel, TAN Standard (TANST) and TAN new finish (TANNEW). Surgery was performed on 7 sheep, with 18 implants per sheep, for a total of 63 implants. After 8 weeks, the specimens were harvested and evaluated macroscopically, radiologically, biomechanically (removal torque), histomorphometrically and histologically. RESULTS: Cobalt-Chrome screws showed significantly (p = 0.031) lower removal torque values than pure titanium screws and also a tendency towards lower values compared to the other materials, except for steel. Steel screws showed no significant differences, in comparison to cobalt-chrome and TANST, however also a trend towards lower torque values than the remaining materials. The results of the fluorescence sections agreed with those of the biomechanical test. Histomorphometrically, there were no significant differences of bone area between the groups. The BIC (bone-to-implant-contact), used for the assessment of the osseointegration, was significantly lower for cobalt-chrome, compared to steel (p = 0.001). Steel again showed a lower ratio (p = 0.0001) compared to the other materials. CONCLUSION: This study demonstrated that cobalt-chrome and steel show less osseointegration than the other metals and metal-alloys. However, osseointegration of cobalt-chrome was improved by zirconium and/or titanium based coatings (CCTC, TANST, TAN, TANNEW) being similar as pure titanium in their osseointegrative behavior. BioMed Central 2012-03-08 /pmc/articles/PMC3315746/ /pubmed/22400715 http://dx.doi.org/10.1186/1471-2474-13-32 Text en Copyright ©2012 Plecko et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Plecko, Michael
Sievert, Christine
Andermatt, Daniel
Frigg, Robert
Kronen, Peter
Klein, Karina
Stübinger, Stefan
Nuss, Katja
Bürki, Alexander
Ferguson, Stephen
Stoeckle, Ulrich
von Rechenberg, Brigitte
Osseointegration and biocompatibility of different metal implants - a comparative experimental investigation in sheep
title Osseointegration and biocompatibility of different metal implants - a comparative experimental investigation in sheep
title_full Osseointegration and biocompatibility of different metal implants - a comparative experimental investigation in sheep
title_fullStr Osseointegration and biocompatibility of different metal implants - a comparative experimental investigation in sheep
title_full_unstemmed Osseointegration and biocompatibility of different metal implants - a comparative experimental investigation in sheep
title_short Osseointegration and biocompatibility of different metal implants - a comparative experimental investigation in sheep
title_sort osseointegration and biocompatibility of different metal implants - a comparative experimental investigation in sheep
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315746/
https://www.ncbi.nlm.nih.gov/pubmed/22400715
http://dx.doi.org/10.1186/1471-2474-13-32
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