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Probing the acceptor substrate binding site of Trypanosoma cruzi trans-sialidase with systematically modified substrates and glycoside libraries

Systematically modified octyl galactosides and octyl N-acetyllactosamines were assessed as inhibitors of, and substrates for, T. cruzi trans-sialidase (TcTS) in the context of exploring its acceptor substrate binding site. These studies show that TcTS, which catalyses the α-(2→3)-sialylation of non-...

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Detalles Bibliográficos
Autores principales:	Harrison, Jennifer A., Kartha, K. P. Ravindranathan, Fournier, Eric J. L., Lowary, Todd L., Malet, Carles, Nilsson, Ulf J., Hindsgaul, Ole, Schenkman, Sergio, Naismith, James H., Field, Robert A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royal Society of Chemistry 2011
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315775/ https://www.ncbi.nlm.nih.gov/pubmed/21253654 http://dx.doi.org/10.1039/c0ob00826e

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