Nitric oxide–dependent Src activation and resultant caveolin-1 phosphorylation promote eNOS/caveolin-1 binding and eNOS inhibition

Endothelial nitric oxide synthase (eNOS)–mediated NO production plays a critical role in the regulation of vascular function and pathophysiology. Caveolin-1 (Cav-1) binding to eNOS holds eNOS in an inactive conformation; however, the mechanism of Cav-1–mediated inhibition of activated eNOS is unclea...

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Detalles Bibliográficos
Autores principales: Chen, Zhenlong, Bakhshi, Farnaz R., Shajahan, Ayesha N., Sharma, Tiffany, Mao, Mao, Trane, Andy, Bernatchez, Pascal, van Nieuw Amerongen, Geerten P., Bonini, Marcelo G., Skidgel, Randal A., Malik, Asrar B., Minshall, Richard D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2012
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315804/
https://www.ncbi.nlm.nih.gov/pubmed/22323292
http://dx.doi.org/10.1091/mbc.E11-09-0811

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