Cargando…
Laquinimod, a Quinoline-3-Carboxamide, Induces Type II Myeloid Cells That Modulate Central Nervous System Autoimmunity
Laquinimod is a novel oral drug that is currently being evaluated for the treatment of relapsing-remitting (RR) multiple sclerosis (MS). Using the animal model for multiple sclerosis, experimental autoimmune encephalomyelitis (EAE), we examined how laquinimod promotes immune modulation. Oral laquini...
Autores principales: | Schulze-Topphoff, Ulf, Shetty, Aparna, Varrin-Doyer, Michel, Molnarfi, Nicolas, Sagan, Sharon A., Sobel, Raymond A., Nelson, Patricia A., Zamvil, Scott S. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3316495/ https://www.ncbi.nlm.nih.gov/pubmed/22479444 http://dx.doi.org/10.1371/journal.pone.0033797 |
Ejemplares similares
-
Treatment of spontaneous EAE by laquinimod reduces Tfh, B cell aggregates, and disease progression
por: Varrin-Doyer, Michel, et al.
Publicado: (2016) -
Tob1 plays a critical role in the activation of encephalitogenic T cells in CNS autoimmunity
por: Schulze-Topphoff, Ulf, et al.
Publicado: (2013) -
MHC class II–dependent B cell APC function is required for induction of CNS autoimmunity independent of myelin-specific antibodies
por: Molnarfi, Nicolas, et al.
Publicado: (2013) -
Immunodominant T-cell epitopes of MOG reside in its transmembrane and cytoplasmic domains in EAE
por: Shetty, Aparna, et al.
Publicado: (2014) -
MOG transmembrane and cytoplasmic domains contain highly stimulatory T-cell epitopes in MS
por: Varrin-Doyer, Michel, et al.
Publicado: (2014)