Spironolactone Lowers Portal Hypertension by Inhibiting Liver Fibrosis, ROCK-2 Activity and Activating NO/PKG Pathway in the Bile-Duct-Ligated Rat

OBJECTIVE: Aldosterone, one of the main peptides in renin angiotensin aldosterone system (RAAS), has been suggested to mediate liver fibrosis and portal hypertension. Spironolactone, an aldosterone antagonist, has beneficial effect on hyperdynamic circulation in clinical practice. However, the mecha...

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Detalles Bibliográficos
Autores principales: Luo, Wei, Meng, Ying, Ji, Hong-Li, Pan, Chun-Qiu, Huang, Shan, Yu, Chang-Hui, Xiao, Li-Ming, Cui, Kai, Ni, Shu-Yuan, Zhang, Zhen-Shu, Li, Xu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3316615/
https://www.ncbi.nlm.nih.gov/pubmed/22479572
http://dx.doi.org/10.1371/journal.pone.0034230

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