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Allelic Ratios and the Mutational Landscape Reveal Biologically Significant Heterozygous SNVs

The issue of heterozygosity continues to be a challenge in the analysis of genome sequences. In this article, we describe the use of allele ratios to distinguish biologically significant single-nucleotide variants from background noise. An application of this approach is the identification of lethal...

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Detalles Bibliográficos
Autores principales:	Chu, Jeffrey S.-C., Johnsen, Robert C., Chua, Shu Yi, Tu, Domena, Dennison, Mark, Marra, Marco, Jones, Steven J. M., Baillie, David L., Rose, Ann M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Genetics Society of America 2012
Materias:	Investigations
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3316639/ https://www.ncbi.nlm.nih.gov/pubmed/22267497 http://dx.doi.org/10.1534/genetics.111.137208

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