“Point” Centromeres of Saccharomyces Harbor Single Centromere-Specific Nucleosomes

The “point” centromere of budding yeast is genetically defined by an ∼125-bp sequence. Recent fluorescence measurements of kinetochore clusters have suggested that this sequence specifies multiple centromere histone 3 (CenH3) nucleosomes. However, high-resolution mapping demonstrates that there is o...

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Detalles Bibliográficos
Autores principales: Henikoff, Steven, Henikoff, Jorja G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Genetics Society of America 2012
Materias:
Notes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3316665/
https://www.ncbi.nlm.nih.gov/pubmed/22234856
http://dx.doi.org/10.1534/genetics.111.137711
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author Henikoff, Steven
Henikoff, Jorja G.
author_facet Henikoff, Steven
Henikoff, Jorja G.
author_sort Henikoff, Steven
collection PubMed
description The “point” centromere of budding yeast is genetically defined by an ∼125-bp sequence. Recent fluorescence measurements of kinetochore clusters have suggested that this sequence specifies multiple centromere histone 3 (CenH3) nucleosomes. However, high-resolution mapping demonstrates that there is only one CenH3 nucleosome per centromere, providing biochemical confirmation of the point centromere model.
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spelling pubmed-33166652012-04-06 “Point” Centromeres of Saccharomyces Harbor Single Centromere-Specific Nucleosomes Henikoff, Steven Henikoff, Jorja G. Genetics Notes The “point” centromere of budding yeast is genetically defined by an ∼125-bp sequence. Recent fluorescence measurements of kinetochore clusters have suggested that this sequence specifies multiple centromere histone 3 (CenH3) nucleosomes. However, high-resolution mapping demonstrates that there is only one CenH3 nucleosome per centromere, providing biochemical confirmation of the point centromere model. Genetics Society of America 2012-04 /pmc/articles/PMC3316665/ /pubmed/22234856 http://dx.doi.org/10.1534/genetics.111.137711 Text en Copyright © 2012 by the Genetics Society of America Available freely online through the author-supported open access option.
spellingShingle Notes
Henikoff, Steven
Henikoff, Jorja G.
“Point” Centromeres of Saccharomyces Harbor Single Centromere-Specific Nucleosomes
title “Point” Centromeres of Saccharomyces Harbor Single Centromere-Specific Nucleosomes
title_full “Point” Centromeres of Saccharomyces Harbor Single Centromere-Specific Nucleosomes
title_fullStr “Point” Centromeres of Saccharomyces Harbor Single Centromere-Specific Nucleosomes
title_full_unstemmed “Point” Centromeres of Saccharomyces Harbor Single Centromere-Specific Nucleosomes
title_short “Point” Centromeres of Saccharomyces Harbor Single Centromere-Specific Nucleosomes
title_sort “point” centromeres of saccharomyces harbor single centromere-specific nucleosomes
topic Notes
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3316665/
https://www.ncbi.nlm.nih.gov/pubmed/22234856
http://dx.doi.org/10.1534/genetics.111.137711
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