Kinetics in Signal Transduction Pathways Involving Promiscuous Oligomerizing Receptors Can Be Determined by Receptor Specificity: Apoptosis Induction by TRAIL

Here we show by computer modeling that kinetics and outcome of signal transduction in case of hetero-oligomerizing receptors of a promiscuous ligand largely depend on the relative amounts of its receptors. Promiscuous ligands can trigger the formation of nonproductive receptor complexes, which slows...

Descripción completa

Detalles Bibliográficos
Autores principales: Szegezdi, Eva, van der Sloot, Almer M., Mahalingam, Devalingam, O'Leary, Lynda, Cool, Robbert H., Muñoz, Inés G., Montoya, Guillermo, Quax, Wim J., de Jong, Steven, Samali, Afshin, Serrano, Luis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Biochemistry and Molecular Biology 2012
Materias:
Special Issue: Prospects in Space and Time
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3316727/
https://www.ncbi.nlm.nih.gov/pubmed/22213832
http://dx.doi.org/10.1074/mcp.M111.013730

Ejemplares similares

Ejemplares similares