Where Do AQP4 Antibodies Fit in the Pathogenesis of NMO?

Recent advances in the field of neuromyelitis optica (NMO) research provided convincing evidence that anti-AQP4 antibody (AQP4-Ab) not only serves as a highly specific disease marker, but also plays an essential role in the pathogenesis of the disease. Although it is now widely recognized that AQP4-...

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Detalles Bibliográficos
Autores principales: Kinoshita, Makoto, Nakatsuji, Yuji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3316941/
https://www.ncbi.nlm.nih.gov/pubmed/22530129
http://dx.doi.org/10.1155/2012/862169
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author Kinoshita, Makoto
Nakatsuji, Yuji
author_facet Kinoshita, Makoto
Nakatsuji, Yuji
author_sort Kinoshita, Makoto
collection PubMed
description Recent advances in the field of neuromyelitis optica (NMO) research provided convincing evidence that anti-AQP4 antibody (AQP4-Ab) not only serves as a highly specific disease marker, but also plays an essential role in the pathogenesis of the disease. Although it is now widely recognized that AQP4-Ab induces astrocytic necrosis in a complement-dependent manner, additional triggers are also suspected as a prerequisite for the development of the disease. Unraveling these unresolved aspects of the disease will provide substantial insight into still controversial issues in the pathogenesis of NMO.
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spelling pubmed-33169412012-04-23 Where Do AQP4 Antibodies Fit in the Pathogenesis of NMO? Kinoshita, Makoto Nakatsuji, Yuji Mult Scler Int Review Article Recent advances in the field of neuromyelitis optica (NMO) research provided convincing evidence that anti-AQP4 antibody (AQP4-Ab) not only serves as a highly specific disease marker, but also plays an essential role in the pathogenesis of the disease. Although it is now widely recognized that AQP4-Ab induces astrocytic necrosis in a complement-dependent manner, additional triggers are also suspected as a prerequisite for the development of the disease. Unraveling these unresolved aspects of the disease will provide substantial insight into still controversial issues in the pathogenesis of NMO. Hindawi Publishing Corporation 2012 2012-03-12 /pmc/articles/PMC3316941/ /pubmed/22530129 http://dx.doi.org/10.1155/2012/862169 Text en Copyright © 2012 M. Kinoshita and Y. Nakatsuji. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Kinoshita, Makoto
Nakatsuji, Yuji
Where Do AQP4 Antibodies Fit in the Pathogenesis of NMO?
title Where Do AQP4 Antibodies Fit in the Pathogenesis of NMO?
title_full Where Do AQP4 Antibodies Fit in the Pathogenesis of NMO?
title_fullStr Where Do AQP4 Antibodies Fit in the Pathogenesis of NMO?
title_full_unstemmed Where Do AQP4 Antibodies Fit in the Pathogenesis of NMO?
title_short Where Do AQP4 Antibodies Fit in the Pathogenesis of NMO?
title_sort where do aqp4 antibodies fit in the pathogenesis of nmo?
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3316941/
https://www.ncbi.nlm.nih.gov/pubmed/22530129
http://dx.doi.org/10.1155/2012/862169
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