Cargando…

Brain Metastases from Endometrial Carcinoma

This paper will focus on knowledge related to brain metastases from endometrial carcinoma. To date, 115 cases were documented in the literature with an incidence of 0.6% among endometrial carcinoma patients. The endometrial carcinoma was usually an advanced-stage and high-grade tumor. In most patien...

Descripción completa

Detalles Bibliográficos
Autores principales: Piura, Ettie, Piura, Benjamin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scholarly Research Network 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3316970/
https://www.ncbi.nlm.nih.gov/pubmed/22523707
http://dx.doi.org/10.5402/2012/581749
_version_ 1782228479440322560
author Piura, Ettie
Piura, Benjamin
author_facet Piura, Ettie
Piura, Benjamin
author_sort Piura, Ettie
collection PubMed
description This paper will focus on knowledge related to brain metastases from endometrial carcinoma. To date, 115 cases were documented in the literature with an incidence of 0.6% among endometrial carcinoma patients. The endometrial carcinoma was usually an advanced-stage and high-grade tumor. In most patients (~90%), brain metastasis was detected after diagnosis of endometrial carcinoma with a median interval from diagnosis of endometrial carcinoma to diagnosis of brain metastases of 17 months. Brain metastasis from endometrial carcinoma was either an isolated disease limited to the brain only (~50%) or part of a disseminated disease involving also other parts of the body (~50%). Most often, brain metastasis from endometrial carcinoma affected the cerebrum (~75%) and was solitary (~60%). The median survival after diagnosis of brain metastases from endometrial carcinoma was 5 months; however, a significantly better survival was achieved with multimodal therapy including surgical resection or stereotactic radiosurgery followed by whole brain radiotherapy (WBRT) and/or chemotherapy compared to WBRT alone. It is suggested that brain imaging studies should be considered in the routine follow up of patients with endometrial carcinoma and that the search for a primary source in females with brain metastases of unknown primary should include endometrial biopsy.
format Online
Article
Text
id pubmed-3316970
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher International Scholarly Research Network
record_format MEDLINE/PubMed
spelling pubmed-33169702012-04-20 Brain Metastases from Endometrial Carcinoma Piura, Ettie Piura, Benjamin ISRN Oncol Review Article This paper will focus on knowledge related to brain metastases from endometrial carcinoma. To date, 115 cases were documented in the literature with an incidence of 0.6% among endometrial carcinoma patients. The endometrial carcinoma was usually an advanced-stage and high-grade tumor. In most patients (~90%), brain metastasis was detected after diagnosis of endometrial carcinoma with a median interval from diagnosis of endometrial carcinoma to diagnosis of brain metastases of 17 months. Brain metastasis from endometrial carcinoma was either an isolated disease limited to the brain only (~50%) or part of a disseminated disease involving also other parts of the body (~50%). Most often, brain metastasis from endometrial carcinoma affected the cerebrum (~75%) and was solitary (~60%). The median survival after diagnosis of brain metastases from endometrial carcinoma was 5 months; however, a significantly better survival was achieved with multimodal therapy including surgical resection or stereotactic radiosurgery followed by whole brain radiotherapy (WBRT) and/or chemotherapy compared to WBRT alone. It is suggested that brain imaging studies should be considered in the routine follow up of patients with endometrial carcinoma and that the search for a primary source in females with brain metastases of unknown primary should include endometrial biopsy. International Scholarly Research Network 2012-03-18 /pmc/articles/PMC3316970/ /pubmed/22523707 http://dx.doi.org/10.5402/2012/581749 Text en Copyright © 2012 E. Piura and B. Piura. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Piura, Ettie
Piura, Benjamin
Brain Metastases from Endometrial Carcinoma
title Brain Metastases from Endometrial Carcinoma
title_full Brain Metastases from Endometrial Carcinoma
title_fullStr Brain Metastases from Endometrial Carcinoma
title_full_unstemmed Brain Metastases from Endometrial Carcinoma
title_short Brain Metastases from Endometrial Carcinoma
title_sort brain metastases from endometrial carcinoma
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3316970/
https://www.ncbi.nlm.nih.gov/pubmed/22523707
http://dx.doi.org/10.5402/2012/581749
work_keys_str_mv AT piuraettie brainmetastasesfromendometrialcarcinoma
AT piurabenjamin brainmetastasesfromendometrialcarcinoma