Cargando…
Brain Metastases from Endometrial Carcinoma
This paper will focus on knowledge related to brain metastases from endometrial carcinoma. To date, 115 cases were documented in the literature with an incidence of 0.6% among endometrial carcinoma patients. The endometrial carcinoma was usually an advanced-stage and high-grade tumor. In most patien...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Scholarly Research Network
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3316970/ https://www.ncbi.nlm.nih.gov/pubmed/22523707 http://dx.doi.org/10.5402/2012/581749 |
_version_ | 1782228479440322560 |
---|---|
author | Piura, Ettie Piura, Benjamin |
author_facet | Piura, Ettie Piura, Benjamin |
author_sort | Piura, Ettie |
collection | PubMed |
description | This paper will focus on knowledge related to brain metastases from endometrial carcinoma. To date, 115 cases were documented in the literature with an incidence of 0.6% among endometrial carcinoma patients. The endometrial carcinoma was usually an advanced-stage and high-grade tumor. In most patients (~90%), brain metastasis was detected after diagnosis of endometrial carcinoma with a median interval from diagnosis of endometrial carcinoma to diagnosis of brain metastases of 17 months. Brain metastasis from endometrial carcinoma was either an isolated disease limited to the brain only (~50%) or part of a disseminated disease involving also other parts of the body (~50%). Most often, brain metastasis from endometrial carcinoma affected the cerebrum (~75%) and was solitary (~60%). The median survival after diagnosis of brain metastases from endometrial carcinoma was 5 months; however, a significantly better survival was achieved with multimodal therapy including surgical resection or stereotactic radiosurgery followed by whole brain radiotherapy (WBRT) and/or chemotherapy compared to WBRT alone. It is suggested that brain imaging studies should be considered in the routine follow up of patients with endometrial carcinoma and that the search for a primary source in females with brain metastases of unknown primary should include endometrial biopsy. |
format | Online Article Text |
id | pubmed-3316970 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | International Scholarly Research Network |
record_format | MEDLINE/PubMed |
spelling | pubmed-33169702012-04-20 Brain Metastases from Endometrial Carcinoma Piura, Ettie Piura, Benjamin ISRN Oncol Review Article This paper will focus on knowledge related to brain metastases from endometrial carcinoma. To date, 115 cases were documented in the literature with an incidence of 0.6% among endometrial carcinoma patients. The endometrial carcinoma was usually an advanced-stage and high-grade tumor. In most patients (~90%), brain metastasis was detected after diagnosis of endometrial carcinoma with a median interval from diagnosis of endometrial carcinoma to diagnosis of brain metastases of 17 months. Brain metastasis from endometrial carcinoma was either an isolated disease limited to the brain only (~50%) or part of a disseminated disease involving also other parts of the body (~50%). Most often, brain metastasis from endometrial carcinoma affected the cerebrum (~75%) and was solitary (~60%). The median survival after diagnosis of brain metastases from endometrial carcinoma was 5 months; however, a significantly better survival was achieved with multimodal therapy including surgical resection or stereotactic radiosurgery followed by whole brain radiotherapy (WBRT) and/or chemotherapy compared to WBRT alone. It is suggested that brain imaging studies should be considered in the routine follow up of patients with endometrial carcinoma and that the search for a primary source in females with brain metastases of unknown primary should include endometrial biopsy. International Scholarly Research Network 2012-03-18 /pmc/articles/PMC3316970/ /pubmed/22523707 http://dx.doi.org/10.5402/2012/581749 Text en Copyright © 2012 E. Piura and B. Piura. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Piura, Ettie Piura, Benjamin Brain Metastases from Endometrial Carcinoma |
title | Brain Metastases from Endometrial Carcinoma |
title_full | Brain Metastases from Endometrial Carcinoma |
title_fullStr | Brain Metastases from Endometrial Carcinoma |
title_full_unstemmed | Brain Metastases from Endometrial Carcinoma |
title_short | Brain Metastases from Endometrial Carcinoma |
title_sort | brain metastases from endometrial carcinoma |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3316970/ https://www.ncbi.nlm.nih.gov/pubmed/22523707 http://dx.doi.org/10.5402/2012/581749 |
work_keys_str_mv | AT piuraettie brainmetastasesfromendometrialcarcinoma AT piurabenjamin brainmetastasesfromendometrialcarcinoma |